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Image Unavailable-BOSSBS-6634R-FITC

Anti-XPC Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Katalógové číslo: (BOSSBS-6634R-FITC)
Dodávateľ: BIOSS INC
Opis: Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
Merná jednotka: 1 * 100 µl
Image Unavailable-SPCMA1293-4LTPV

Ammonia solution 27 - 30% FCC

Dodávateľ: Spectrum Chemical
Opis: Ammonia Solution, FCC is a solution of Ammonia in water. It has many uses, but in food production it is used primarily as a leavening agent. Spectrum Chemical offers over 300 Food Grade (FCC) chemical ingredients packaged in laboratory size bottles to production drum quantities and are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities.

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Image Unavailable-SPCMPH125-4LTPV

Fenol 89,0 USP

Dodávateľ: Spectrum Chemical
Opis: Liquefied Phenol, USP is commonly used for permanent treatment of ingrown toe and finger nails. All Spectrum Chemical USP products USP are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities.

Image Unavailable-SPCML1135-500GM

Locust bean gum FCC

Dodávateľ: Spectrum Chemical
Opis: Locust (Carob) Bean Gum, FCC is a gelling and thickening agent used in certain foods. The FCC grade meets the requirements of the Food Chemical Codex indicates and is suitable for all food, beverage and nutritional supplement applications. Spectrum Chemical offers over 300 Food grade chemical ingredients packaged in laboratory size bottles to production drum quantities and are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities.

Certifikáty

Image Unavailable-SPCMAM175-500GM

Chlorid amonný

Dodávateľ: Spectrum Chemical
Opis: Ammonium Chloride, Granular, USP is used as an expectorant in cough medicine. All Spectrum Chemical USP products are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities

Image Unavailable-BOSSBS-15482R-A555

Anti-hHR23b Rabbit Polyclonal Antibody (ALEXA FLUOR® 555)

Katalógové číslo: (BOSSBS-15482R-A555)
Dodávateľ: BIOSS INC
Opis: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome. Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with CETN2 appears to stabilise XPC. May protect XPC from proteasomal degradation. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognises a wide spectrum of damaged DNA characterised by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognise and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-15482R

Anti-hHR23b Rabbit Polyclonal Antibody

Katalógové číslo: (BOSSBS-15482R)
Dodávateľ: BIOSS INC
Opis: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome. Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with CETN2 appears to stabilise XPC. May protect XPC from proteasomal degradation. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognises a wide spectrum of damaged DNA characterised by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognise and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
Merná jednotka: 1 * 100 µl
Image Unavailable-SPCMPO170-500GM

Potassium chloride 99, granular USP

Katalógové číslo: (SPCMPO170-500GM)
Dodávateľ: Spectrum Chemical
Opis: Potassium Chloride, Granular, USP is used to treat hypokalemia. All Spectrum Chemical USP products are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities.
Merná jednotka: 1 * 500 g
Image Unavailable-BOSSBS-6634R-A350

Anti-XPC Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Katalógové číslo: (BOSSBS-6634R-A350)
Dodávateľ: BIOSS INC
Opis: Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
Merná jednotka: 1 * 100 µl
Image Unavailable-SPCMSO187-2.5KG

Dihydrogenfosforečnan sodný, anhydrous 98,0 USP

Katalógové číslo: (SPCMSO187-2.5KG)
Dodávateľ: Spectrum Chemical
Opis: Monobasic Sodium Phosphate, Anhydrous, USP is used as a buffering agent. All Spectrum Chemical USP products are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities
Merná jednotka: 1 * 2,5 kg
Image Unavailable-SPCMAL215-20LT

Almond oil NF, sweet

Dodávateľ: Spectrum Chemical
Opis: Almond oil NF, sweet

Image Unavailable-SPCMSO167-125GM

Sodium fluoride 98,5, powder BP, USP

Katalógové číslo: (SPCMSO167-125GM)
Dodávateľ: Spectrum Chemical
Opis: Sodium Fluoride, Powder, USP, EP, BP is used to prevent cavities making teeth stronger and more resistant to decay caused by acid and bacteria. Toothpaste being the preferred delivery method. All Spectrum Chemical USP, EP, BP products are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities.
Merná jednotka: 1 * 125 g
Image Unavailable-SPCMPE125-174KGBL

Petrolatum, white USP

Dodávateľ: Spectrum Chemical
Opis: Petrolatum, White, USP is used as a moisturizer to treat or prevent dry, rough, scaly, itchy skin and minor skin irritations. All Spectrum Chemical USP products are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities

Image Unavailable-SPCMVI140-100ML

DL-α-Tocopherol acetate USP

Katalógové číslo: (SPCMVI140-100ML)
Dodávateľ: Spectrum Chemical
Opis: Vitamin E Acetate, USP is used as an antioxidant. All Spectrum Chemical USP products are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities.
Merná jednotka: 1 * 100 mL
Image Unavailable-SPCMF1135-2.5LTGL

Formic acid FCC

Dodávateľ: Spectrum Chemical
Opis: Formic Acid, FCC is the simplest carboxylic acid and one of its biggest uses is as a preservative and antibacterial agent in livestock feed. The FCC grade meets the requirements of the Food Chemical Codex indicates and is suitable for all food, beverage and nutritional supplement applications. Spectrum Chemical offers over 300 Food grade chemical ingredients packaged in laboratory size bottles to production drum quantities and are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities.

Image Unavailable-SPCMH1335-125GM

Hydroxypropyl methylcellulose (Hypromellose), 4000 mPa.s USP Substitution Type 2910

Katalógové číslo: (SPCMH1335-125GM)
Dodávateľ: Spectrum Chemical
Opis: Hypromellose, Substitution Type 2910, 4000 mPa.s, USP is an artificial tear used to relieve dry eye conditions. All Spectrum Chemical USP products are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities
Merná jednotka: 1 * 125 g
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