Hľadali ste: 2-Benzoylbenzoic+acid

Dodávateľ: Thermo Fisher Scientific

Opis: Holmium tribromide hydrate ≥99.99% (REO, rare earth oxide basis), REacton®

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Dodávateľ: Apollo Scientific

Opis: Moniliformin sodium salt (from Fusarium moniliforme)

Dodávateľ: Thermo Fisher Scientific

Opis: Methylsalicylát ≥98%

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Katalógové číslo: (0421-1KG)

Dodávateľ: VWR Chemicals

Opis: Animal-free amino acid. Polar. Acidic.

Merná jednotka: 1 * 1 kg

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Dodávateľ: Thermo Fisher Scientific

Opis: 10-Bromo-1-decanol 95%

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Katalógové číslo: (APOSOR315399-100G)

Dodávateľ: Apollo Scientific

Opis: 11-Bromo-1-undecanol

Merná jednotka: 1 * 100 g

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Dodávateľ: Thermo Fisher Scientific

Opis: 10-Bromo-1-decanol 95%

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Katalógové číslo: (59004.)

Dodávateľ: BIOTIUM

Opis: Ready-to-use solution of Pluronic® F-127, a nonionic detergent useful for solubilizing hydrophobic dye molecules such as cell-permeable AM esters of Fura-2, Fluo-3, Indo-1, or Rhod-2 calcium indicators to facilitate cell loading.

Merná jednotka: 1 * 1 mL

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Dodávateľ: Thermo Fisher Scientific

Opis: Holmium trichloride hexahydrate ≥99.9% (REO, rare earth oxide basis), REacton®

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Katalógové číslo: (ENZOADIOSA400E)

Dodávateľ: ENZO LIFE SCIENCES

Opis: Cleavage of heme b (Fe-protoporphyrin IX) at the a-methene carbon bridge to form the open tetrapyrrole, biliverdin IXa and carbon monoxide (CO) is catalyzed by heme oxygenase (HO) isozymes HO-1 and HO-2 (heme hydrogen-donor: oxygen oxidoreductase; EC 1.14.99.3). In mammalian species, biliverdin reductase (BVR; bilirubin: NAD(P)+ oxidoreductase; EC 1.3.1.24) converts the open tetrapyrrole to bilirubin. This pathway represents the only efficient way of making bilirubin and thereby deterring activation of oxygen by the heme molecule. HO-1 belongs to the heat shock protein family (Hsp32), while HO-2 takes a constitutive form expressed at exceedingly high levels in the brain and testes. The end products of the heme degradation process carry out important physiological activities. CO may act as a messenger in the brain and systemic organs stimulating cGMP-production through interactions with the heme-dependent form of guanylate cyclase. Bile pigments display potent antioxidant activity as well as effective antiviral activity against HIV and herpes virus. BVR is unique among all enzymes characterized to date in having two pH optima (6.8 and 8.7), using a different cofactor at each pH range (NADH at pH 7.0 and NADPH at pH 8.7). The enzyme displays pI and molecular mass microheterogeneity, apparently a result of post translational modifications. In rat, the enzyme also shows a tissue specific developmental pattern. BVR is not inactivated by heat shock, and its preexisting message is not sequestered from translation subsequent to thermal stress. Furthermore, reductase preserves microheterogeneity under thermal stress. BVR expression occurs not only in cells and brain regions that already display HO-1 and HO-2, but also in regions and cell types with potential to induce stress proteins. Rat cDNA for BVR has been isolated and characterized. The deduced protein contains 3 cysteine residues (Cys73, Cys281, and Cys290) involved in cofactor and substrate binding. Human BVR consists of a substantially longer polypeptide than the rat enzyme (41-42 kDa vs. 33 kDa), but also is dual cofactor and dual pH dependent, requires free SH groups for activity, and displays pI and molecular mass microheterogeneity. The human and rat BVR share some antigenic epitopes and show immunochemical cross reactivity.

Merná jednotka: 1 * 100 µG

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Dodávateľ: Apollo Scientific

Opis: Holmium trichloride hexahydrate 98%

Katalógové číslo: (20350.232)

Dodávateľ: VWR Chemicals

Opis: Kyselina L(+)-glutamová 98.5-100.5% Ph. Eur.

Merná jednotka: 1 * 250 g

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Dodávateľ: ENZO LIFE SCIENCES

Opis: Heme Oxygenase-1 (HO-1) also known as Hsp32, is the inducible isoform of heme oxygenase that catalyzes the NADPH, oxygen, and cytochrome P450 reductase dependent oxidation of heme to carbon monoxide, ferrous iron and biliverdin which is rapidly reduced to bilirubin. These products of the HO reaction have important physiological effects: carbon monoxide is a potent vasodilator and has been implicated to be a physiological regulator of cGMP and vascular tone; biliverdin and its product bilirubin are potent antioxidants; "free" iron increases oxidative stress and regulates the expression of many mRNAs (e.g., DCT-1, ferritin and transferring receptor) by affecting the conformation of iron regulatory protein (IRP)-1 and its binding to iron regulatory elements (IREs) in the 5'- or 3'- UTRs of the mRNAs. To date, three identified heme oxygenase isoforms are part of the HO system that catalyze heme into biliverdin and carbon monoxide. These are inducible HO-1 or Hsp32, constitutive HO-2 that is abundant in the brain and testis, and HO-3 which is related to HO-2 but is the product of a different gene. The HO system is the rate-limiting step in heme degradation and HO activity decreases the levels of heme which is a well known potent catalyst of lipid peroxidation and oxygen radical formation.

Katalógové číslo: (472020010.)

Dodávateľ: Thermo Fisher Scientific

Opis: Undecaethylene glycol 95%

Merná jednotka: 1 * 1 g

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Dodávateľ: Thermo Fisher Scientific

Opis: Methyl hydrogen malonate 96%

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Katalógové číslo: (BOSSBS-1238R-A750)

Dodávateľ: BIOSS INC

Opis: Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter.

Merná jednotka: 1 * 100 µl

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