Hľadali ste: quick-disconnect+fittings

Opis: Ready-to-use solution of Pluronic® F-127, a nonionic detergent useful for solubilizing hydrophobic dye molecules such as cell-permeable AM esters of Fura-2, Fluo-3, Indo-1, or Rhod-2 calcium indicators to facilitate cell loading.

Katalógové číslo: 59004.

Merná jednotka: 1 * 1 mL

Dodávateľ: BIOTIUM

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Opis: Undecaethylene glycol 95%

Katalógové číslo: 472020010.

Merná jednotka: 1 * 1 g

Dodávateľ: Thermo Fisher Scientific

New Product Predaj

Opis: Cleavage of heme b (Fe-protoporphyrin IX) at the a-methene carbon bridge to form the open tetrapyrrole, biliverdin IXa and carbon monoxide (CO) is catalyzed by heme oxygenase (HO) isozymes HO-1 and HO-2 (heme hydrogen-donor: oxygen oxidoreductase; EC 1.14.99.3). In mammalian species, biliverdin reductase (BVR; bilirubin: NAD(P)+ oxidoreductase; EC 1.3.1.24) converts the open tetrapyrrole to bilirubin. This pathway represents the only efficient way of making bilirubin and thereby deterring activation of oxygen by the heme molecule. HO-1 belongs to the heat shock protein family (Hsp32), while HO-2 takes a constitutive form expressed at exceedingly high levels in the brain and testes. The end products of the heme degradation process carry out important physiological activities. CO may act as a messenger in the brain and systemic organs stimulating cGMP-production through interactions with the heme-dependent form of guanylate cyclase. Bile pigments display potent antioxidant activity as well as effective antiviral activity against HIV and herpes virus. BVR is unique among all enzymes characterized to date in having two pH optima (6.8 and 8.7), using a different cofactor at each pH range (NADH at pH 7.0 and NADPH at pH 8.7). The enzyme displays pI and molecular mass microheterogeneity, apparently a result of post translational modifications. In rat, the enzyme also shows a tissue specific developmental pattern. BVR is not inactivated by heat shock, and its preexisting message is not sequestered from translation subsequent to thermal stress. Furthermore, reductase preserves microheterogeneity under thermal stress. BVR expression occurs not only in cells and brain regions that already display HO-1 and HO-2, but also in regions and cell types with potential to induce stress proteins. Rat cDNA for BVR has been isolated and characterized. The deduced protein contains 3 cysteine residues (Cys73, Cys281, and Cys290) involved in cofactor and substrate binding. Human BVR consists of a substantially longer polypeptide than the rat enzyme (41-42 kDa vs. 33 kDa), but also is dual cofactor and dual pH dependent, requires free SH groups for activity, and displays pI and molecular mass microheterogeneity. The human and rat BVR share some antigenic epitopes and show immunochemical cross reactivity.

Katalógové číslo: ENZOADIOSA400E

Merná jednotka: 1 * 100 µG

Dodávateľ: ENZO LIFE SCIENCES

New Product Predaj

Opis: Kyselina L(+)-glutamová 98,5-100,5 Ph. Eur.

Katalógové číslo: 20350.232

Merná jednotka: 1 * 250 g

Dodávateľ: VWR Chemicals

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Opis: Holmium trichloride hexahydrate 99,9 REO basis, REacton®

Katalógové číslo: 11277.22

Merná jednotka: 1 * 100 g

Dodávateľ: Thermo Fisher Scientific

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Opis: Kyselina šťavelová dihydrát 99,5-102,5 ACS

Katalógové číslo: 33262.30

Merná jednotka: 1 * 250 g

Dodávateľ: Thermo Fisher Scientific

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Opis: Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter.

Katalógové číslo: BOSSBS-1238R-A750

Merná jednotka: 1 * 100 µl

Dodávateľ: BIOSS INC

Predaj

Opis: Selective inhibitor of CDK1/cyclin B (IC50=20nM). Potent cytotoxin in tumor cells: IC50=5.3µM against MCF7 cells, IC50=11.1µM against K562 cells, IC50=3.0µM against CEM cells, IC50=6.3µM against HOS cells, and IC50=6.3µM against G361 cells.

Katalógové číslo: ENZOALX270396M005

Merná jednotka: 1 * 5 mg

Dodávateľ: ENZO LIFE SCIENCES

New Product Predaj

Opis: This antibody recognizes CD16 (FcγRIII), the low-affinity receptor for IgG with an apparent molecular weight of 50-80 kDa. Two similar genes represent CD16, CD16A (FcγRIIIA), which exists as a hetero-oligomeric polypeptide-anchored form in macrophages and NK cells and CD16B (FcγRIIIB), which exist as a monomeric GPI-anchored form in neutrophils. Furthermore, there are two known polymorphisms of CD16B, NA-1 and NA-2. Individuals homozygous for NA-2 show a lower phagocytic capacity compared with NA-1. CD16 binds IgG in the form of immune complexes and shows preferential binding of IgG1 and IgG3 isotypes and minimal binding of IgG2 and IgG4. Upon IgG binding, both CD16 isoforms initiate signal transduction cascades that lead to a variety of responses including antibody-dependent cell-mediated cytotoxicity (ADCC), phagocytosis, degranulation and proliferation.

Katalógové číslo: BNC881056-100

Merná jednotka: 1 * 100 µl

Dodávateľ: BIOTIUM

Predaj

Opis: This antibody recognizes CD16 (FcγRIII), the low-affinity receptor for IgG with an apparent molecular weight of 50-80 kDa. Two similar genes represent CD16, CD16A (FcγRIIIA), which exists as a hetero-oligomeric polypeptide-anchored form in macrophages and NK cells and CD16B (FcγRIIIB), which exist as a monomeric GPI-anchored form in neutrophils. Furthermore, there are two known polymorphisms of CD16B, NA-1 and NA-2. Individuals homozygous for NA-2 show a lower phagocytic capacity compared with NA-1. CD16 binds IgG in the form of immune complexes and shows preferential binding of IgG1 and IgG3 isotypes and minimal binding of IgG2 and IgG4. Upon IgG binding, both CD16 isoforms initiate signal transduction cascades that lead to a variety of responses including antibody-dependent cell-mediated cytotoxicity (ADCC), phagocytosis, degranulation and proliferation.

Katalógové číslo: BNUB1056-500

Merná jednotka: 1 * 500 µl

Dodávateľ: BIOTIUM

Predaj

Opis: Ready-to-use solution of Pluronic® F-127, a nonionic detergent useful for solubilizing hydrophobic dye molecules such as AM esters of Fura-2, Fluo-3, Indo-1, or Rhod-2 to facilitate cell loading.

Katalógové číslo: 59005.

Merná jednotka: 1 * 30 mL

Dodávateľ: BIOTIUM

Predaj

Opis: This antibody recognizes CD16 (FcγRIII), the low-affinity receptor for IgG with an apparent molecular weight of 50-80 kDa. Two similar genes represent CD16, CD16A (FcγRIIIA), which exists as a hetero-oligomeric polypeptide-anchored form in macrophages and NK cells and CD16B (FcγRIIIB), which exist as a monomeric GPI-anchored form in neutrophils. Furthermore, there are two known polymorphisms of CD16B, NA-1 and NA-2. Individuals homozygous for NA-2 show a lower phagocytic capacity compared with NA-1. CD16 binds IgG in the form of immune complexes and shows preferential binding of IgG1 and IgG3 isotypes and minimal binding of IgG2 and IgG4. Upon IgG binding, both CD16 isoforms initiate signal transduction cascades that lead to a variety of responses including antibody-dependent cell-mediated cytotoxicity (ADCC), phagocytosis, degranulation and proliferation.

Katalógové číslo: BNUM1056-50

Merná jednotka: 1 * 50 µl

Dodávateľ: BIOTIUM

Predaj

Opis: Kyselina L(+)-glutamová

Katalógové číslo: A1704.1000

Merná jednotka: 1 * 1 kg

Dodávateľ: PanReac AppliChem

Predaj

Opis: Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter.

Katalógové číslo: BOSSBS-1238R-A680

Merná jednotka: 1 * 100 µl

Dodávateľ: BIOSS INC

Predaj

Opis: Kyselina L(+)-glutamová 98,5-101,5 USP, multi-compendial, J.T.Baker®

Katalógové číslo: 2077-06

Merná jednotka: 1 * 1 kg

Dodávateľ: Avantor

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Opis: Standardy - holmium, 1000 mg/L, VWR®, Holmium, Matrice: Nitric acid dil., Aplikace: Standardy AAS

Katalógové číslo: 86683.260

Merná jednotka: 1 * 500 mL

Dodávateľ: VWR Chemicals

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