Hľadali ste: ENZO LIFE SCIENCES

Dodávateľ: ENZO LIFE SCIENCES

Opis: Precursor to 1α,25-dihydroxyvitamin D₃

New Product

Katalógové číslo: (ENZOBMLEI1000001)

Dodávateľ: ENZO LIFE SCIENCES

Opis: Lipoxygenase inhibitor

Merná jednotka: 1 * 1 g

New Product Predaj

Katalógové číslo: (ENZOBMLEA1040005)

Dodávateľ: ENZO LIFE SCIENCES

Opis: NMDA receptor antagonist.

Merná jednotka: 1 * 5 mg

New Product Predaj

Katalógové číslo: (ENZOBMLEI1180010)

Dodávateľ: ENZO LIFE SCIENCES

Opis: A potent and specific substrate analog PLA2 inhibitor (IC50=6.2 µM-porcine pancreatic PLA2). It inhibits human recombinant sPLA2 (IC50=13.7 µM) selectively over cPLA2. At 1 µM it completely blocked the myogenic response in perfused dog renal arcuate arteries.

Merná jednotka: 1 * 10 mg

New Product Predaj

Katalógové číslo: (ENZOBMLEI1051000)

Dodávateľ: ENZO LIFE SCIENCES

Opis: Cytochrome P450 inhibitor

Merná jednotka: 1 * 1 g

New Product Predaj

Katalógové číslo: (ENZOADICSA330E)

Dodávateľ: ENZO LIFE SCIENCES

Opis: The epidermal growth factor receptor (EGFR) is a 170-kDa membrane bound receptor consisting of an extracellular ligand-binding domain, a single hydrophobic transmembrane region, and a tyrosine kinase domain-containing cytoplasmic region. Ligand binding induces receptor homo- or heterodimerization, triggering autophosphorylation of cytoplasmic tyrosine residues that provide docking sites for Src homology 2 (SH2) domain-containing signaling molecules. Src-mediated phosphorylation of EGFR at Tyr845 may contribute to EGFR hyperactivity in cancer, while autophosphorylation of EGFR at Tyr1068 and/or Tyr1173 in response to ligand binding is known to recruit cofactors (e.g. SHP1, RasGAP, SOS1, Grb2) that activate pathways associated with cell growth, apoptosis, adhesion, receptor endocytosis, and protein degradation.

Merná jednotka: 1 * 100 µG

New Product Predaj

Dodávateľ: ENZO LIFE SCIENCES

Opis: Bad is an important regulatory protein involved in the control of cell survival and apoptosis, and is a member of the BH3-only family of proteins such as Bim and Bid that share homology with Bcl-2 only in the BH3 domain. Phosphorylated Bad is sequestered in the cytosol by 14-3-3 proteins under normal conditions, but is dephosphorylated and activated following apoptotic signals. Apoptotic stimuli induce Bad dephosphorylation by a number of phosphatases (e.g., calcineurin) and recruitment to the mitochondria, where Bad heterodimerizes with and inhibits prosurvival proteins of the Bcl family. In contrast, survival signals lead to phosphorylation of Bad at multiple serine residues, including phosphorylation at Ser112 and Ser136 which induce association with 14-3-3 proteins. Phosphorylation at Ser112 and Ser136 is required for a third phosphorylation event at Ser155, which induces dissociation of Bad/Bcl heterodimers to promote cell survival. This antibody specifically binds the Bad protein, but does not recognize Bad/Bcl-2 heterodimers in immunoprecipitation assays.

New Product

Katalógové číslo: (ENZOADIAAM175E)

Dodávateľ: ENZO LIFE SCIENCES

Opis: Cytochrome c is an electron transport protein from mitochondria.  A primary means of caspase activation by p53 is through induction of cytochrome c release from mitochondria.  Cleavage of Bid, a Bcl 2 family member, by caspase-8 produces a truncated tBid molecule which triggers mitochondria release of cytochrome c which binds to the adaptor protein Apaf-1 and procaspase-9 to form a cytosolic apoptosome complex.  This event results in activation of procaspase-9 and its subsequent cleavage and activation of caspase-3 leading to the degradation of a series of cellular substrates and subsequently cell death.

Merná jednotka: 1 * 100 µG

New Product Predaj

Katalógové číslo: (ENZOADIAAM141E)

Dodávateľ: ENZO LIFE SCIENCES

Opis: BID is a cytosolic protein that is cleaved by caspase-8 in response to death receptor stimulation.

Merná jednotka: 1 * 100 µG

New Product Predaj

Katalógové číslo: (ENZOADICOX030E)

Dodávateľ: ENZO LIFE SCIENCES

Opis: COX-2 catalyze a cyclooxygenase (bis-oxygenase) reaction in which arachidonate plus two molecules of O2 are converted to PGG2 (prostaglandin G2), and a peroxidase reaction in which PGG2 undergoes a two-electron reduction to PGH2.

Merná jednotka: 1 * 100 µG

New Product Predaj

Katalógové číslo: (ENZOBMLEI1770001)

Dodávateľ: ENZO LIFE SCIENCES

Opis: Phospholipase inhibitor

Merná jednotka: 1 * 1 mg

New Product Predaj

Dodávateľ: ENZO LIFE SCIENCES

Opis: AACOCF3 is a trifluoromethylketone derivative of arachidonic acid. It is a selective inhibitor of human cytosolic PLA2 and Ca2+-independent PLA2 (iPLA2, IC50=15 µM). It is active in intact platelets and U937 cells (IC50=8 µM). It also inhibits fatty acid amide hydrolase (100% at 7.5 µM).

New Product

Katalógové číslo: (ENZOENZCHM2020010)

Dodávateľ: ENZO LIFE SCIENCES

Opis: Selective MEK inhibitor

Merná jednotka: 1 * 10 mg

New Product Predaj

Katalógové číslo: (ENZOBMLPW94000025)

Dodávateľ: ENZO LIFE SCIENCES

Opis: Host: Mouse, Isotype: IgG1

Merná jednotka: 1 * 25 µl

New Product Predaj

Dodávateľ: ENZO LIFE SCIENCES

Opis: The proteasome is widely recognised as the central enzyme of non-lysosomal protein degradation. It is responsible for intracellular protein turnover and it is also critically involved in many regulatory processes and, in higher eukaryotes, in antigen processing.

New Product

Dodávateľ: ENZO LIFE SCIENCES

Opis: Recombinant PI31 has been shown to compete with the proteasome regulators PA28 and 19S PA700 for binding to 20S, indicating that PI31 binds the 20S α-rings and may function by hindering substrate access to the 20S catalytic channel.

New Product