Hľadali ste: Biosensis

Katalógové číslo: (BSENM-1573-100)

Dodávateľ: BIOSENSIS PTY

Opis: Protein DJ-1 has many roles including protecting cells against oxidative stress and cell death (Ref: SwissProt). Mutations in the DJ-1 gene have been associated with rare forms of autosomal recessive early-onset Parkinson's disease.

Merná jednotka: 1 * 100 µG

Predaj

Katalógové číslo: (BSENM-1325-100)

Dodávateľ: BIOSENSIS PTY

Opis: Clone OX-42 recognises the rat equivalent of human CD11b. CD11b is a single-pass type I membrane protein that belongs to the integrin alpha chain family. CD11b is predominantly expressed in monocytes and granulocytes and is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles (Ref: SWISSPROT). CD11b is also frequently used as a microglial marker allowing to distinguish between quiescent and activated microglia based on the intensity of CD11b staining.

Merná jednotka: 1 * 100 µG

Predaj

Katalógové číslo: (BSENM-1376-250)

Dodávateľ: BIOSENSIS PTY

Opis: Glyceraldehyde 3-Phosphate Dehydrogenase (GAPDH) is a metabolic enzyme responsible for catalyzing one step in the glycolytic pathway, the reversible oxidative phosphorylation of glyceraldehyde 3-phosphate. GAPDH may have other roles in the activation of transcription and in the regulation of apoptosis as well as Alzheimer's disease and Huntington's disease. The immunogen used to raise this particular antibody was extensively purified pig GAPDH. This antibody can be used as a loading control for western blotting experiments, allowing comparison between the level of this protein and others in a cell or tissue.

Merná jednotka: 1 * 250 µl

Predaj

Katalógové číslo: (BSENM-1572-100)

Dodávateľ: BIOSENSIS PTY

Opis: 14.3.3 protein eta or 14.3.3  binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (Ref SwissProt). 14.3.3 protein eta is widely expressed as both homodimers and heterodimers and are concentrated in the nervous system. High concentrations of 14.3.3 protein eta have been linked to Creutzfeld Jacob Disease, Parkinson's Disease and early-onset schizopherenia.

Merná jednotka: 1 * 100 µG

Predaj

Katalógové číslo: (BSENC-1409-50)

Dodávateľ: BIOSENSIS PTY

Opis: Vimentins are class-III intermediate filaments specific to mesenchymal tissue. Vimentin is an important cytoskeletal component responsible for maintaining cell integrity and has a probable role in the intracellular transport of proteins such as lipoproteins between the nucleus and plasma membrane. Immunohistochemical staining for Vimentin is characteristic of sarcomas. 

Merná jednotka: 1 * 50 µl

Predaj

Katalógové číslo: (BSENM-1391-50)

Dodávateľ: BIOSENSIS PTY

Opis: Neurofilaments are composed of three intermediate filament proteins: light (~68 kDa), medium (~160 kDa) and heavy (~200 kDa), which are involved in the maintenance of the neuronal caliber. Neurofilament light (NF68 or NF-L) is the most abundant of the three proteins.

Merná jednotka: 1 * 50 µl

Predaj

Katalógové číslo: (BSENM-026-50-AT)

Dodávateľ: BIOSENSIS PTY

Opis: Monoclonal antibody MC192 against the rat low affinity nerve growth factor receptor (p75NTR) is derived from the fusion of Sp2/0-Ag 14 myeloma cells with mouse immune splenocytes. MC192 monoclonal antibody was originally generated by Chandlers et al. p75NTR was originally discovered as a low affinity nerve growth factor receptor. Later it was found that it was the receptor for all neurotrophins. It mediates signals of neurotrophins for neuronal survival, apoptosis, neurite outgrowth and synaptic plasticity. Recently, it has been revealed that p75NTR not only acts as the receptor for neurotrophins but also the receptor for many other pathological ligands such as prions, rabies virus and amyloid beta. p75NTR also acts as a co-receptor for NOGO which mediates inhibitory signals of myelin associated protein. p75NTR is highly expressed in a number of non-neuronal and neuronal cells including motor neurons during development and also in damaged neurons. MC192 has a potential use as the ligand for gene delivery into p75NTR-expressing rat cells via a receptor-mediated mechanism.
This antibody reacts with rat only. Does not react with mouse or human NGFR

Merná jednotka: 1 * 50 µG

Predaj

Katalógové číslo: (BSENM-1400-100)

Dodávateľ: BIOSENSIS PTY

Opis: Anti-PRPH Mouse Monoclonal Antibody [clone: 7C5]

Merná jednotka: 1 * 100 µG

Predaj

Katalógové číslo: (BSENM-1836-100)

Dodávateľ: BIOSENSIS PTY

Opis: The protein named TrkB (also named Neurotrophic tyrosine kinase receptor type 2 (NTRK2), GP145-TrkB or Tropomyosin-related kinase B is a receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems and is important in the regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. TrkB may also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia. TrkB is the primary receptor for BDNF (brain-derived neurotrophic factor. TrkB also binds NT4 and NT3 but less efficiently. (Reference: www.uniprot.org).

Applications: Flow Cytometry (5-10 ug/mL): Tested on human and rodent cell lines. Cell staining can be performed under native conditions on ice, or on fixed cells with up to 4% formaldehyde. Other applications have not been tested. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.

Merná jednotka: 1 * 100 µG

Predaj

Katalógové číslo: (BSENC-1801-50)

Dodávateľ: BIOSENSIS PTY

Opis: Calretinin is a calcium-binding protein which is abundant in auditory neurons. Ref: uniprot.org. Antibody is specific for calretinin and does not recognize closely related proteins parvalbumin and calbindin as determined by Western Blotting.

Merná jednotka: 1 * 50 µl

Predaj

Katalógové číslo: (BSENR-1808-100)

Dodávateľ: BIOSENSIS PTY

Opis: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organisation of cells into tissues during embryonic development by interacting with other extracellular matrix components. Ref: uniprot.org. This antibody recognizes laminin isotypes alpha-1 (440 kDa), beta-1 (220 kDa) and gamma-1 (220 kDa). It also binds laminin binding protein at 120 kDa which always co-expresses with laminin.

Merná jednotka: 1 * 100 µG

Predaj

Katalógové číslo: (BSENM-1818-100)

Dodávateľ: BIOSENSIS PTY

Opis: NGF receptor antibody clone 8J2 was developed specifically as a replacement for clone MLR2, which is no longer available anywhere for commercial use. Antibody reactivity for clone 8J2 has been validated for human, mouse and rat extracellular domain of p75NTR. Clone 8J2 has been demonstrated to perform equivalent to or better than MLR2 antibody in all testing.

Merná jednotka: 1 * 100 µG

Predaj

Katalógové číslo: (BSENS-1754-500)

Dodávateľ: BIOSENSIS PTY

Opis: Sheep serum from non-immunised animals was purified by protein G affinity chromatography. This sheep IgG fraction can be used as negative control antibody for various immunological techniques where sheep primary antibodies are used.

Merná jednotka: 1 * 500 µG

Predaj

Katalógové číslo: (BSENM-1805-100)

Dodávateľ: BIOSENSIS PTY

Opis: Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable). Ref: uniprot.org

Merná jednotka: 1 * 100 µG

Predaj

Katalógové číslo: (BSENC-1812-50)

Dodávateľ: BIOSENSIS PTY

Opis: Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). Ref: uniprot.org

Merná jednotka: 1 * 50 µl

Predaj

Katalógové číslo: (BSENG-1784-100)

Dodávateľ: BIOSENSIS PTY

Opis: Apolipoprotein E (ApoE) is a lipoprotein involved in fat metabolism and acts as cholesterol carrier between cells and across tissues. On a genetic level, three APOE alleles are described, APOE2, APOE3 and APOE4. These alleles give rise to six APOE isoforms, which are differentially implicated in various diseases. In the peripheral system, APOE4 is linked to increased risk of atherosclerosis. In the CNS, the ability of APOE4 in clearing beta-amyloid is impaired, while APOE3 and APOE2 are more efficient in performing this task. The APOE4 genotype in particular has been linked to increased risk for developing Alzheimer's Disease.

Merná jednotka: 1 * 100 µG

Predaj