Hľadali ste: Biosensis

Katalógové číslo: (BSENC-1532-100)

Dodávateľ: BIOSENSIS PTY

Opis: FUNCTION: Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity. SUBCELLULAR LOCATION: Endoplasmic reticulum; rough endoplasmic reticulum. Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses. SIMILARITY: Belongs to the orexin family.

Merná jednotka: 1 * 100 µl

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Katalógové číslo: (BSENR-017-500)

Dodávateľ: BIOSENSIS PTY

Opis: BDNF belongs to the neurotrophin family and regulates the survival and differentiation of neurons during development. The alterations in BDNF expression induced by various kinds of brain insult including stress, ischemia, seizure activity and hypoglycemia, may contribute to some pathologies such as depression, epilepsy, Alzheimer's, and Parkinson's disease. Microglia release BDNF that may contribute to neuroinflammation and neuropathic pain. FUNCTION: Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB. SUBCELLULAR LOCATION: Secreted protein. Post Translation Modification (PTM): The propeptide is N-glycosylated and glycosulfated. PTM: Converted into mature BDNF by plasmin (PLG) (By similarity). DISEASE: Defects in BDNF are a cause of congenital central hypoventilation syndrome (CCHS); also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. CCHS is frequently complicated with neurocristopathies such as Hirschsprung disease that occurs in about 16% of CCHS cases. SIMILARITY: Belongs to the NGF-beta family.

Merná jednotka: 1 * 500 µG

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Katalógové číslo: (BSENM-006-100)

Dodávateľ: BIOSENSIS PTY

Opis: Monoclonal antibody MC192 against the rat low affinity nerve growth factor receptor (p75NTR) is derived from the fusion of Sp2/0-Ag 14 myeloma cells with mouse immune splenocytes. MC192 monoclonal antibody was originally generated by Chandlers et al. p75NTR was originally discovered as a low affinity nerve growth factor receptor. Later it was found that it was the receptor for all neurotrophins. It mediates signals of neurotrophins for neuronal survival, apoptosis, neurite outgrowth and synaptic plasticity. Recently, it has been revealed that p75NTR is not only acts as the receptor for neurotrophins but also the receptor for many other pathological ligands such as prions, rabies virus and amyloid beta. p75NTR also acts as a co-receptor for NOGO which mediates inhibitory signals of myelin associated protein. p75NTR is highly expressed in a number of non-neuronal and neuronal cells including motor neurons during development and also in damaged neurons. MC192 recognizes the extracellular domain of the neurotrophin receptor p75NTR in rat. MC192 antibody may be used for immunocytochemical localisation of rat cells expressing p75NTR, ELISA and western blot. This antibody has also been used for the construction of the MC192-saporin immunotoxin for specific elimination of neuronal populations in basal forebrain cholinergic neurons to generate an animal model for Alzheimer's disease. Using Flow Cytometry, this antibody has frequently been employed for panning to isolate p75NTR-expressing rat cells. MC192 has a potential use as the ligand for gene delivery into p75NTR-expressing rat cells via a receptor-mediated mechanism. FUNCTION: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. SUBUNIT: Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with NGFRAP1/BEX3. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1 (By similarity). Interacts with BEX1. SUBCELLULAR LOCATION: Membrane; single-pass type I membrane protein. DOMAIN: Death domain is responsible for interaction with RANBP9. PTM: N- and O-glycosylated. PTM: Phosphorylated on serine residues. SIMILARITY: Contains 1 death domain. SIMILARITY: Contains 4 TNFR-Cys repeats.

Merná jednotka: 1 * 100 µG

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Katalógové číslo: (BSENR-1550-100)

Dodávateľ: BIOSENSIS PTY

Opis: The Endothelin B receptor is a multi-pass membrane protein that belongs to the G-protein coupled receptor 1 family. It acts as a non-specific receptor for endothelin 1, 2, and 3.

Merná jednotka: 1 * 100 µl

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Katalógové číslo: (BSENR-1571-100)

Dodávateľ: BIOSENSIS PTY

Opis: Protein painting of fourth (Pof) is a probable RNA-binding protein that binds to the fourth chromosome and may bind a RNA that spreads the fourth chromosome (Ref: Swissprot).

Merná jednotka: 1 * 100 µG

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Katalógové číslo: (BSENS-052-500)

Dodávateľ: BIOSENSIS PTY

Opis: FUNCTION: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons. SUBUNIT: Homodimer, associated by noncovalent forces. SUBCELLULAR LOCATION: Secreted protein. SIMILARITY: Belongs to the NGF-beta family.

Merná jednotka: 1 * 500 µG

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Katalógové číslo: (BSENTR-300-AG)

Dodávateľ: BIOSENSIS PTY

Opis: Amylo-Glo RTD reagent is designed to stain amyloid plaques in tissue sections.

Merná jednotka: 1 * 1 KIT

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Katalógové číslo: (BSENM-1689-100)

Dodávateľ: BIOSENSIS PTY

Opis: Anti-LMNA Mouse T4 Antibody [clone: 4C4]

Merná jednotka: 1 * 100 µG

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Katalógové číslo: (BSENM-1646-100)

Dodávateľ: BIOSENSIS PTY

Opis: Anti-ACTA Mouse T4 Antibody [clone: 5J11]

Merná jednotka: 1 * 100 µG

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Katalógové číslo: (BSENR-1717-50)

Dodávateľ: BIOSENSIS PTY

Opis: Anti-TrkB (phospho Y816/Y817) Rabbit Polyclonal Antibody

Merná jednotka: 1 * 50 µG

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Katalógové číslo: (BSENBEK-2240-2P)

Dodávateľ: BIOSENSIS PTY

Opis: The Biosensis Mature BDNF/proBDNF Combo RapidTM enzyme-linked immunosorbent assay (ELISA) Kit combines individual, but complementary ELISA kits for the two most important BDNF isoforms: Mature BDNF (BSENBEK-2211) and full-length proBDNF (BSENBEK-2217).

Merná jednotka: 1 * 192 Tests

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Katalógové číslo: (BSENM-1802-50)

Dodávateľ: BIOSENSIS PTY

Opis: May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin. Ref: uniprot.org

Merná jednotka: 1 * 50 µG

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Katalógové číslo: (BSENR-1794-100)

Dodávateľ: BIOSENSIS PTY

Opis: Beta-casein has an important role in determination of the surface properties of the casein micelles. it is cleaved into 3 chains (casoparan, casohypotensin and antioxidant peptide). Casoparan acts as a macrophage activator, increasing the phagocytic activity of macrophages and peroxide release from macrophages. It also acts as a bradykinin-potentiating peptide. Casohypotensin acts as a bradykinin-potentiating peptide and induces hypotension in rats. Acts as a strong competitive inhibitor of endo-oligopeptidase A. Antioxidant peptide has antioxidant activity.

Merná jednotka: 1 * 100 µl

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Dodávateľ: BIOSENSIS PTY

Opis: MC192-saporin is an antibody conjugate comprising of the monoclonal antibody MC192 against rat p75NTR, the nerve growth factor receptor, chemically conjugated via a reducible disulfide bridge to the ribosome-inactivating protein saporin, purified from saponaria officinalis.

Katalógové číslo: (BSENM-1763-100-FT)

Dodávateľ: BIOSENSIS PTY

Opis: Mouse monoclonal antibody (Clone X63) with no known antigen binding ability was purified from hybridoma cell culture medium by Protein G chromatography and labelled with FITC. X63-FITC is useful as a negative control antibody for immunofluorescence studies using FITC-labelled primary antibodies.

Merná jednotka: 1 * 100 µl

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Katalógové číslo: (BSENTR-150-FJB)

Dodávateľ: BIOSENSIS PTY

Opis: The causes and effects of neuronal degeneration are of major interest to a wide variety of neuroscientists. Paralleling this growing interest is an increasing number of methods applicable to the detection of neuronal degeneration. The fluorescent dye Fluoro-Jade® B (FJB), like its more purified brother Fluoro-Jade® C (FJC), is an anionic fluorescein derivative useful for the histological staining of neurons undergoing degeneration.

Merná jednotka: 1 * 30 mg

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