Hľadali ste: Tonbo Biosciences

Dodávateľ: TONBO BIOSCIENCE

Opis: The SK3 antibody reacts with human CD4, a 59 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta-2 domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4, and co-receptors CCR5 and CXCR4, may also be utilized by HIV-1 to enter T cells. Human CD4 is typically expressed on thymocytes, some mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells. The SK3 antibody is widely used as a phenotypic marker for human CD4 expression, and has been reported to be cross-reactive with Rhesus and Cynomolgus CD4. This antibody does not block binding of alternative clone RPA-T4, suggesting that they recognize different epitopes.

Katalógové číslo: (67-4724-U100)

Dodávateľ: TONBO BIOSCIENCE

Opis: The C1.18.4 immunoglobulin is useful as an isotype-matched control. The C.1.18.4 immunolglobulin has an unknown binding specificity and is used as an isotype control for mouse IgG2a antibodies.

Merná jednotka: 1 * 100 µG

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Dodávateľ: TONBO BIOSCIENCE

Opis: The SN5c antibody is specific for human CD10, a 100 kDa type II transmembrane protein also known as Common Acute Lymphoblastic Leukemia Antigen (CALLA). In normal cells, it is expressed on early B and T lymphoid precursors, neutrophils and on various epithelia. CD10 is also expressed on several lymphoma cells including Burkitt�s, acute lymphoblastic, and follicular germinal center lymphomas. CD10 functions as an endopeptidase and is involved in B cell development, as well as a mediator of neutrophil inflammatory responses.

Dodávateľ: TONBO BIOSCIENCE

Opis: The Human Basic B Lymphocyte backbone panel is a six-color combination of anti-human antibodies. This panel can serve as a backbone to identify the various B lymphocyte subsets, including naive, memory and plasma cells. This panel configuration leaves room for GFP or additional drop-in markers, if desired. Violet laser (405 nm) required for detection of CD45 violetFluoTM 450.

Katalógové číslo: (40-4031-U100)

Dodávateľ: TONBO BIOSCIENCE

Opis: The LTF-2 immunoglobulin is useful as an isotype-matched control. The LTF-2 immunolglobulin has an unknown binding specificity and is used as an isotype control for rat IgG2b antibodies.

Merná jednotka: 1 * 100 µG

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Katalógové číslo: (40-4732-U100)

Dodávateľ: TONBO BIOSCIENCE

Opis: The MPC-11 immunoglobulin is useful as an isotype-matched control. The MPC-11 immunolglobulin has an unknown binding specificity and is used as an isotype control for mouse IgG2b antibodies.

Merná jednotka: 1 * 100 µG

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Dodávateľ: TONBO BIOSCIENCE

Opis: The XMG1.2 antibody is specific for mouse Interferon-gamma (IFN-g), a 20 kDa type II cytokine known for its central roles in protection against bacterial or viral pathogens and for its anti-tumor properties. IFN-g is secreted by several types of immune cells which allow the cytokine to modulate innate immunity when secreted by NK and NKT cells, and to function in support of adaptive immunity when secreted by Th1 and CD8+ T cells (CTLs).

Dodávateľ: TONBO BIOSCIENCE

Opis: The RM134L antibody recognizes CD252, also known as OX-40 Ligand or CD134 Ligand, a member of the TNF superfamily that is present on the surface of antigen presenting cells and activated B lymphocytes. The OX-40 Ligand interacts with OX-40 (CD134) which is expressed primarily on activated T cells. This costimulatory interaction leads to increased proliferation and IL-2 production responses of activated T cells, and at the same time enhances proliferation and immunoglobulin secretion by activated B cells.

Dodávateľ: TONBO BIOSCIENCE

Opis: The MP4-25D2 antibody is specific for human IL-4, a pleiotropic cytokine that Th2 cell differentiation, B cell proliferation and differentiation, and B cell class switching to IgE. MP4-25D2 is a neutralizing antibody and is reported to cross react with rhesus monkey IL-4.

Dodávateľ: TONBO BIOSCIENCE

Opis: The HI30 antibody reacts with human CD45, one of the most abundant hematopoietic markers and one that is expressed on all leukocytes (the Leukocyte Common Antigen, LCA). CD45 is a protein tyrosine phosphatase existing in several isoforms, each being generated and expressed in cell-specific patterns. With its broad cell distribution, CD45 is critical for many leukocyte functions, regulating signal transduction and cell activation associated with the T cell receptor, B cell receptor, and IL-2 receptor. Other forms of CD45, with restricted cellular expression, include CD45R (B220), CD45RA, CD45RB, CD45RO and others.

Dodávateľ: TONBO BIOSCIENCE

Opis: The Hit8a antibody is specific for the 32-34 kDa alpha chain of human CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor for antigen recognition and subsequent T cell activation that is initiated upon binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck, facilitating intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death of tumor cells, as well as cells infected by virus, bacteria or parasites.

Dodávateľ: TONBO BIOSCIENCE

Opis: The OKT3 antibody is specific for human CD3e, also known as CD3 epsilon, a 20 kDa subunit of the T cell receptor complex along with CD3 gamma and CD3 delta. These integral membrane protein chains assemble with additional chains of the T cell receptor (TCR), as well as CD3 zeta chain, to form the T cell receptor – CD3 complex. Together with co-receptors CD4 or CD8, the complex serves to recognize antigens bound to MHC molecules on antigen-presenting cells. These interactions promote T cell receptor signaling (T cell activation), inducing a number of cellular responses including proliferation, differentiation, production of cytokines or activation-induced cell death. CD3 is differentially expressed during thymocyte-to-T cell development and on all mature T cells.

Katalógové číslo: (13-0879-T100)

Dodávateľ: TONBO BIOSCIENCE

Opis: Ghost Dye™ Violet 540 is an amine reactive viability dye that can be used to discriminate viable from non-viable mammalian cells in flow cytometry applications

Merná jednotka: 1 * 100 Tests

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Katalógové číslo: (35-8027-M001)

Dodávateľ: TONBO BIOSCIENCE

Opis: Goat anti-Human IgE (epsilon chain) - Affinity Pure, FITC Conjugate, min x w/bovine, mouse or rabbit serum proteins

Merná jednotka: 1 * 1 mg

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Katalógové číslo: (30-8028-M001)

Dodávateľ: TONBO BIOSCIENCE

Opis: Goat anti-Human IgM (mu chain) - Affinity Pure, Biotin Conjugate

Merná jednotka: 1 * 1 mg

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Katalógové číslo: (70-8024-M001)

Dodávateľ: TONBO BIOSCIENCE

Opis: Goat anti-Human IgE (epsilon chain) - Affinity Pure, min x w/bovine, mouse or rabbit serum proteins

Merná jednotka: 1 * 1 mg

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