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Image Unavailable-BOSSBS-6634R-CY5.5

Anti-XPC Rabbit Polyclonal Antibody (Cy5.5®)

Opis: Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
Katalógové číslo: BOSSBS-6634R-CY5.5
Merná jednotka: 1 * 100 µl
Dodávateľ: BIOSS INC
Product Image-171-2709

Accessories for VWR® Water Purification System

Opis: FLODEM single-use demineralisation cartridge, VWR®
Katalógové číslo: 171-2709
Merná jednotka: 1 * 1 items
Dodávateľ: VWR Collection
Product Image-MFLX76000-00

Masterflex® Single-Use Replacement Pump Heads for Quattroflow Pump Systems

Opis: Keep your Quattroflow™ pump system up and running with these quality replacement pump heads.
Katalógové číslo: MFLX76000-00
Merná jednotka: 1 * 1 items
Dodávateľ: Avantor Fluid Handling
Product Image-590-0734

Accessories for SCAT Level Controls

Opis: Necessary and helpful accessories for use with SCAT electronic level controls.
Katalógové číslo: 590-0734
Merná jednotka: 1 * 1 items
Dodávateľ: S.C.A.T.
Image Unavailable-734-3342

VWR®, Accessories for Avantor TopMixer Single-Use Open Top Mixing Systems

Opis: Single-Use LDPE tank with bottom port, 50L, VWR®
Katalógové číslo: 734-3342
Merná jednotka: 1 * 1 items
Dodávateľ: VWR Collection
Image Unavailable-BOSSBS-6634R-CY3

Anti-XPC Rabbit Polyclonal Antibody (Cy3®)

Opis: Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
Katalógové číslo: BOSSBS-6634R-CY3
Merná jednotka: 1 * 100 µl
Dodávateľ: BIOSS INC
Image Unavailable-BOSSBS-6634R-HRP

Anti-XPC Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Opis: Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
Katalógové číslo: BOSSBS-6634R-HRP
Merná jednotka: 1 * 100 µl
Dodávateľ: BIOSS INC
Product Image-MFLX30719-04

Masterflex® Single-Use Filling Needles

Opis: A high-quality engineered solution for every application in the fill-finish workflow.
Katalógové číslo: MFLX30719-04
Merná jednotka: 1 * 1 items
Dodávateľ: Avantor Fluid Handling

Certifikáty


Image Unavailable-462-0553

VWR®, External PT100 Probe for Chillers

Opis: External PT100 probe is used for with chillers and coolers, 6000 series chiller, non-refrigerated coolers, 4100 liquid-to-liquid coolers.
Katalógové číslo: 462-0553
Merná jednotka: 1 * 1 items
Dodávateľ: VWR Collection
Product Image-461-3534

Precision PT100 reference sensors

Opis: Sensor is suitable for use with calibration baths.
Katalógové číslo: 461-3534
Merná jednotka: 1 * 1 items
Dodávateľ: JULABO GMBH
Image Unavailable-SH31141.01

Chlorid sodný solution 2 M, in single-use containers, HyClone™ for bioprocessing

Opis: HyClone™ NaCl solutions in single-use bags offer a convenient format for many upstream and downstream bioprocessing applications.
Katalógové číslo: SH31141.01
Merná jednotka: 1 * 1 L
Dodávateľ: HyClone products (Cytiva)
Image Unavailable-VEPA3FSKS610506

Single Use Test Packs, Bowie and Dick Type

Opis: Indikátory sterilizace, Bowie-dick single use test pack (prime-pack)
Katalógové číslo: VEPA3FSKS610506
Merná jednotka: 1 * 50 items
Dodávateľ: VP Medical Packaging

New Product


Product Image-662-9217

pH electrodes for field measurements, Polyplast™

Opis: Polyplast electrodes have a shatterproof plastic shaft. They are ideal for portable measurements or as entry level sensors for basic laboratory applications.
Katalógové číslo: 662-9217
Merná jednotka: 1 * 1 items
Dodávateľ: HAMILTON BONADUZ
Product Image-ENTEDSU-00-01-00

Dispensing head, Sentry®

Opis: Designed for use with FluoroPure® single-use HDPE blowmolded drums, this single-use dispense head provides dispensing functions in a single connection.
Katalógové číslo: ENTEDSU-00-01-00
Merná jednotka: 1 * 1 items
Dodávateľ: ENTEGRIS
Product Image-734-2944

VWR®, Single-Use Tank Liners, Medical Grade

Opis: These tank liners are single-use bags with an open top, designed to fit in cylindrical vessels.
Katalógové číslo: 734-2944
Merná jednotka: 1 * 20 items
Dodávateľ: VWR Collection

Certifikáty


Image Unavailable-76470-110

VWR®, Sterile Masks

Opis: VWR® made in USA sterile masks are an ideal option for single-use needs.
Katalógové číslo: 76470-110
Merná jednotka: 1 * 200 items
Dodávateľ: VWR Collection
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