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Product Image-40-0801-U100

Anti-CD80 Armenian Hamster Antibody [clone: 16-10A1]

Katalógové číslo: (40-0801-U100)
Dodávateľ: TONBO BIOSCIENCE
Opis: The 16-10A1 antibody reacts with mouse CD80, also known as B7-1, a 55 kDa type I transmembrane protein ligand for CD152 (CTLA-4) and for CD28, a co-stimulatory receptor for the T cell receptor (TCR). CD28 also binds a second B7 ligand known as CD86 (B7-2). Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 or CTLA-4 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response.
Merná jednotka: 1 * 100 µG
Product Image-50-1152-U100

Anti-CSF1R rat antibody (PE (Phycoerythrin)) [clone: AFS98]

Katalógové číslo: (50-1152-U100)
Dodávateľ: TONBO BIOSCIENCE
Opis: The AFS98 antibody is specific for mouse CD115, also known as Colony-Stimulating Factor-1 Receptor (CSF-1R), a 145 kDa receptor from the PDGF receptor family. Receptor activation by the ligands IL-34 or CSF-1 (M-CSF) occurs via homodimerization of CD115 and subsequent tyrosine phosphorylation and ubiquitination of intracellular domains. CD115 signalling promotes differentiation of myeloid precursors, as well as the continued regulation of proliferation, survival and function of mononuclear phagocytes, dendritic cells and osteoclasts. While IL-34 and CSF-1 may induce similar cellular responses, they are differentially expressed and as such exert complimentary actions via CD115.
Merná jednotka: 1 * 100 µG
Product Image-70-0549-U100

Anti-ICAM1 Mouse Antibody [clone: 15.2]

Katalógové číslo: (70-0549-U100)
Dodávateľ: TONBO BIOSCIENCE
Opis: The 15.2 antibody reacts with human CD54, also known as ICAM-1 (Intercellular Adhesion Molecule 1), a 90-110 kDa cell surface glycoprotein that is inducibly expressed on both immune and endothelial cells. As its name implies, ICAM-1 participates in cell-cell adhesion between leukocytes and endothelial cells, facilitating leukocyte recruitment and transmigration at sites of inflammation. The ligands for ICAM-1 are also expressed on leukocyte and endothelial cells, and include Mac-1, fibrinogen, and a member of the integrin protein family, LFA-1 (CD11a).
Merná jednotka: 1 * 100 µG
Image Unavailable-20-4301-U100

Rat IgG1 Isotype Control [clone: HRPN] (APC (Allophycocyanin))

Katalógové číslo: (20-4301-U100)
Dodávateľ: TONBO BIOSCIENCE
Opis: The HRPN immunoglobulin is useful as an isotype-matched control. The HRPN immunolglobulin has an unknown binding specificity and is used as an isotype control for rat IgG1 antibodies.
Merná jednotka: 1 * 100 µG
Image Unavailable-20-4714-U100

Mouse IgG1 Isotype Control [clone: MOPC-21] (APC (Allophycocyanin))

Katalógové číslo: (20-4714-U100)
Dodávateľ: TONBO BIOSCIENCE
Opis: The MOPC-21 immunoglobulin is useful as an isotype-matched control. The MOPC-21 immunolglobulin has an unknown binding specificity and is used as an isotype control for mouse IgG1 antibodies.
Merná jednotka: 1 * 100 µG
Image Unavailable-20-4724-U100

Mouse IgG2a Isotype Control [clone: C1.18.4] (APC (Allophycocyanin))

Katalógové číslo: (20-4724-U100)
Dodávateľ: TONBO BIOSCIENCE
Opis: The C1.18.4 immunoglobulin is useful as an isotype-matched control. The C.1.18.4 immunolglobulin has an unknown binding specificity and is used as an isotype control for mouse IgG2a antibodies.
Merná jednotka: 1 * 100 µG
Product Image-25-1276-U100

Anti-Ly-6G Rat Monoclonal Antibody (APC (Allophycocyanin))/Cy7®) [clone: 1A8]

Katalógové číslo: (25-1276-U100)
Dodávateľ: TONBO BIOSCIENCE
Opis: The 1A8 antibody binds to mouse Ly-6G, commonly known as Gr-1, a member of the Ly-6 superfamily of GPI-anchored cell surface proteins with roles in cell signaling and cell adhesion. Gr-1 is differentially expressed during development and maturation of cells in the myeloid lineage and is expression at varying stages and levels on monocytes, macrophages, granulocytes, and peripheral neutrophils.
Merná jednotka: 1 * 100 µG
Product Image-70-0281-U100

Anti-CD28 Mouse Monoclonal Antibody [clone: 37.51]

Katalógové číslo: (70-0281-U100)
Dodávateľ: TONBO BIOSCIENCE
Opis: The 37.51 antibody reacts with mouse CD28, a 45 kDa glycoprotein which acts as a co-stimulatory receptor in support of the T cell receptor (TCR). CD28 exists as a homodimer with specificity for two known ligands, known as B7-1 (CD80) and B7-2 (CD86), expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction/co-stimulatory signaling between the B7 ligands and CD28 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response. Other members of the CD28 family of co-stimulatory receptors include CTLA-4 (CD152), PD-1 (CD279), ICOS and BTLA.
Merná jednotka: 1 * 100 µG
Product Image-65-1886-U100

Anti-CD8A Rat Monoclonal Antibody (Peridinin Chlorophyll/Cy5.5®) [clone: 2.43]

Katalógové číslo: (65-1886-U100)
Dodávateľ: TONBO BIOSCIENCE
Opis: The 2.43 antibody reacts with the 32 to 34 kDa alpha subunit of mouse CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor in antigen recognition and subsequent T cell activation induced by binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck and facilitate intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death in tumor cells, as well as in cells infected by virus, bacteria or parasites.
Merná jednotka: 1 * 100 µG
Product Image-40-0081-U100

Anti-CD8A Rat Monoclonal Antibody [clone: 53-6.7]

Katalógové číslo: (40-0081-U100)
Dodávateľ: TONBO BIOSCIENCE
Opis: The 53-6.7 antibody reacts with the 32-34 kDa alpha subunit of mouse CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor in antigen recognition and subsequent T cell activation that is initiated upon binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck, facilitating intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death of tumor cells, as well as cells infected by virus, bacteria or parasites.
Merná jednotka: 1 * 100 µG
Product Image-35-1152-U100

Anti-CSF1R Rat Monoclonal Antibody (FITC (Fluorescein)) [clone: AFS98]

Katalógové číslo: (35-1152-U100)
Dodávateľ: TONBO BIOSCIENCE
Opis: The AFS98 antibody is specific for mouse CD115, also known as Colony-Stimulating Factor-1 Receptor (CSF-1R), a 145 kDa receptor from the PDGF receptor family. Receptor activation by the ligands IL-34 or CSF-1 (M-CSF) occurs via homodimerisation of CD115 and subsequent tyrosine phosphorylation and ubiquitination of intracellular domains. CD115 signaling promotes differentiation of myeloid precursors, as well as the continued regulation of proliferation, survival and function of mononuclear phagocytes, dendritic cells and osteoclasts. While IL-34 and CSF-1 may induce similar cellular responses, they are differentially expressed and as such exert complimentary actions via CD115.
Merná jednotka: 1 * 100 µG
Product Image-65-4301-U100

Rat IgG1 Isotype Control [clone: HRPN] (PerCP (Peridinin-Chlorophyll Protein Complex)-Cy5.5®)

Katalógové číslo: (65-4301-U100)
Dodávateľ: TONBO BIOSCIENCE
Opis: The HRPN immunoglobulin is useful as an isotype-matched control. The HRPN immunolglobulin has an unknown binding specificity and is used as an isotype control for rat IgG1 antibodies.
Merná jednotka: 1 * 100 µG
Product Image-20-1172-U100

Anti-KIT Rat Monoclonal Antibody (APC (Allophycocyanin)) [clone: ACK2]

Katalógové číslo: (20-1172-U100)
Dodávateľ: TONBO BIOSCIENCE
Opis: The ACK2 antibody is specific for CD117, also called c-Kit, a 145 kDa cytokine receptor important in the development of hematopoietic stem cells, in oogenesis, and for functional activity of immune cells such as NK and mast cells. c-Kit binds to a ligand known as stem cell factor (SCF), or alternatively as mast cell growth factor. Ligand binding promotes the activation (dimerization) and subsequent tyrosine kinase activity of the c-Kit receptor and triggers key survival, expansion and maturation signals during hematopoietic progenitor cell development. Conversely, shedding of extracellular domain of c-Kit receptor is reported to induce inactivation or apoptosis within these cells. The survival signaling activity of c-Kit confers a proto-oncogenic attribute to the receptor, as overexpression or mutations in this protein are associated with tumor development.
Merná jednotka: 1 * 100 µG

KBÚ – slovenskú verziu si vyžiadajte na regulatory.cz@avatorsciences.com


Product Image-20-0251-U100

Anti-IL2RA Rat Monoclonal Antibody (APC (Allophycocyanin)) [clone: PC61.5]

Katalógové číslo: (20-0251-U100)
Dodávateľ: TONBO BIOSCIENCE
Opis: The PC61.5 antibody is specific for mouse CD25, a 55 kDa surface protein also known as the Interleukin-2 Receptor alpha chain, or IL-2R alpha. CD25 may bind IL-2 by itself, although with low affinity and without induction of cell signaling. CD25 is also expressed within a high-affinity complex, along with the IL-2R beta chain (CD122) and the common gamma chain (CD132), to form a signaling receptor complex. Expression of CD25 varies during developmental stages of T and B cells, is induced on activated mature T and B cells, and is present on subsets of dendritic cells. CD25 signaling as part of the IL-2 receptor complex triggers T cell activation and proliferation, as well as modulating the differentiation and function of Th17 cells, T regulatory (Treg) cells, and dendritic cells.
Merná jednotka: 1 * 100 µG
Product Image-50-0453-U100

Anti-CD45.1 Mouse Monoclonal Antibody (PE (Phycoerythrin)) [clone: A20]

Katalógové číslo: (50-0453-U100)
Dodávateľ: TONBO BIOSCIENCE
Opis: The A20 antibody reacts with mouse CD45.1, also known as Ly5.1, which is a strain-specific allelic form of the CD45 Leukocyte Common Antigen (LCA). Functionally, CD45 is a protein tyrosine phosphatase whose broad cell distribution supports a critical role in many leukocyte functions, including regulation of signal transduction and cell activation associated with the T cell and B cell receptors.
Merná jednotka: 1 * 100 µG
Image Unavailable-65-4031-U100

Rat IgG2b Isotype Control [clone: LTF-2] (PerCP (Peridinin-Chlorophyll Protein Complex)/Cy5.5®)

Katalógové číslo: (65-4031-U100)
Dodávateľ: TONBO BIOSCIENCE
Opis: The LTF-2 immunoglobulin is useful as an isotype-matched control. The LTF-2 immunolglobulin has an unknown binding specificity and is used as an isotype control for rat IgG2b antibodies.
Merná jednotka: 1 * 100 µG
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