Hľadali ste: kat5

Katalógové číslo: (BOSSBS-0076R-A750)

Dodávateľ: BIOSS INC

Opis: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalisation of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1. Beta-amyloid peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. In vitro, can reduce Cu(2+) and Fe(3+) to Cu(+) and Fe(2+), respectively. Beta-amyloid 42 is a more effective reductant than beta-amyloid 40. Beta-amyloid peptides bind to lipoproteins and apolipoproteins E and J in the CSF and to HDL particles in plasma, inhibiting metal-catalysed oxidation of lipoproteins. Beta-APP42 may activate mononuclear phagocytes in the brain and elicit inflammatory responses.

Merná jednotka: 1 * 100 µl

Predaj

Katalógové číslo: (SIALSAB1407003-50)

Dodávateľ: Merck

Opis: ANTI-KAT5 1 * 50 µG

Merná jednotka: 1 * 50 µG

Predaj

Katalógové číslo: (SIALSAB2106496-100)

Dodávateľ: Merck

Opis: ANTI-KAT5 1 * 100 µl

Merná jednotka: 1 * 100 µl

Predaj

Katalógové číslo: (SIALSAB5300083-100)

Dodávateľ: Merck

Opis: MONOCLONAL ANTI-KAT5 1 * 100 µl

Merná jednotka: 1 * 100 µl

Predaj

Katalógové číslo: (ABNOH00010524-PW2)

Dodávateľ: ABNOVA

Opis: KAT5 (HUMAN) IP-WB AB PAIR 1 * 1 SET

Merná jednotka: 1 * 1 SET

Predaj

Katalógové číslo: (ABNOPAB31650)

Dodávateľ: ABNOVA

Opis: KAT5 (PHOSPHO S86) POLYCLONAL ANTIBO 1 * 100 µl

Merná jednotka: 1 * 100 µl

Predaj

Katalógové číslo: (ABNOMAB16675)

Dodávateľ: ABNOVA

Opis: KAT5MAB,CLONE4B3B4 1 * 100 µG

Merná jednotka: 1 * 100 µG

Predaj

Katalógové číslo: (ABNOMAB16680)

Dodávateľ: ABNOVA

Opis: KAT5MAB,CLONE2A11H7 1 * 100 µG

Merná jednotka: 1 * 100 µG

Predaj