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Image Unavailable-BOSSBS-0772R-CY3

Anti-FSCN1 Rabbit Polyclonal Antibody (Cy3®)

Katalógové číslo: (BOSSBS-0772R-CY3)
Dodávateľ: BIOSS INC
Opis: Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration.
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-9307R-CY5.5

Anti-CCP110 Rabbit Polyclonal Antibody (Cy5.5®)

Katalógové číslo: (BOSSBS-9307R-CY5.5)
Dodávateľ: BIOSS INC
Opis: Necessary for centrosome duplication at different stages of procentriole formation. Collaborates with CEP97, being involved in the suppression of a cilia assembly program. Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2.
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-3253R-A680

Anti-LRP6 Ser1490 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Katalógové číslo: (BOSSBS-3253R-A680)
Dodávateľ: BIOSS INC
Opis: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-1911R-A488

Anti-TGM3 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Katalógové číslo: (BOSSBS-1911R-A488)
Dodávateľ: BIOSS INC
Opis: Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold (By similarity). In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath.
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-4117R-HRP

Anti-LRP5 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Katalógové číslo: (BOSSBS-4117R-HRP)
Dodávateľ: BIOSS INC
Opis: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation.
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-4117R-A680

Anti-LRP5 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Katalógové číslo: (BOSSBS-4117R-A680)
Dodávateľ: BIOSS INC
Opis: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation.
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-6465R-A488

Anti-CCDC88A Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Katalógové číslo: (BOSSBS-6465R-A488)
Dodávateľ: BIOSS INC
Opis: Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Essential for the integrity of the actin cytoskeleton and for cell migration. Required for formation of actin stress fibers and lamellipodia. May be involved in membrane sorting in the early endosome.
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-6465R-A750

Anti-Girdin Ser1417 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Katalógové číslo: (BOSSBS-6465R-A750)
Dodávateľ: BIOSS INC
Opis: Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Essential for the integrity of the actin cytoskeleton and for cell migration. Required for formation of actin stress fibers and lamellipodia. May be involved in membrane sorting in the early endosome.
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-3602R-CY3

Anti-ULK1 Rabbit Polyclonal Antibody (Cy3®)

Katalógové číslo: (BOSSBS-3602R-CY3)
Dodávateľ: BIOSS INC
Opis: Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation.
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-3602R-CY7

Anti-ULK1 Rabbit Polyclonal Antibody (Cy7®)

Katalógové číslo: (BOSSBS-3602R-CY7)
Dodávateľ: BIOSS INC
Opis: Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation.
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-3602R-FITC

Anti-ULK1 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Katalógové číslo: (BOSSBS-3602R-FITC)
Dodávateľ: BIOSS INC
Opis: Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation.
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-3602R-CY5

Anti-ULK1 Rabbit Polyclonal Antibody (Cy5®)

Katalógové číslo: (BOSSBS-3602R-CY5)
Dodávateľ: BIOSS INC
Opis: Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation.
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-3464R-CY5

Anti-ULK1 Rabbit Polyclonal Antibody (Cy5®)

Katalógové číslo: (BOSSBS-3464R-CY5)
Dodávateľ: BIOSS INC
Opis: Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation.
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-11051R-A555

Anti-HAPLN2 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Katalógové číslo: (BOSSBS-11051R-A555)
Dodávateľ: BIOSS INC
Opis: HAPLN2 is a 340 amino acid protein encoded by the human gene HAPLN2. HAPLN2 belongs to the HAPLN family and contains one immunoglobulin (Ig)-like, V-type domain and two link domains. HAPLN2 mediates a firm binding of versican V2 to hyaluronic acid. HAPLN2 is believed to play a pivotal role in the formation of the hyaluronan-associated matrix in the central nervous system (CNS), which facilitates neuronal conduction and general structural stabilization. HAPLN2 may also be involved in the formation of extracellular matrices, contributing to perineuronal nets and facilitating the understanding of a functional role of these extracellular matrices. HAPLN2 is found in several nuclei throughout the midbrain and hindbrain in a perineuronal net pattern.
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-3602R-A555

Anti-ULK1 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Katalógové číslo: (BOSSBS-3602R-A555)
Dodávateľ: BIOSS INC
Opis: Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation.
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-5379R-HRP

Anti-PLTP Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Katalógové číslo: (BOSSBS-5379R-HRP)
Dodávateľ: BIOSS INC
Opis: Facilitates the transfer of a spectrum of different lipid molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylglycerol, cerebroside and phosphatidyl ethanolamine. Essential for the transfer of excess surface lipids from triglyceride-rich lipoproteins to HDL, thereby facilitating the formation of smaller lipoprotein remnants, contributing to the formation of LDL, and assisting in the maturation of HDL particles. PLTP also plays a key role in the uptake of cholesterol from peripheral cells and tissues that is subsequently transported to the liver for degradation and excretion. Two distinct forms of PLTP exist in plasma: an active form that can transfer PC from phospholipid vesicles to high-density lipoproteins (HDL), and an inactive form that lacks this capability.
Merná jednotka: 1 * 100 µl
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