Hľadali ste: Termostaty+ob\u011Bhové

Katalógové číslo: (USBIL1670-07K)

Dodávateľ: UNITED BIOCHEMICALS

Opis: Anti-LEP Rabbit Polyclonal Antibody

Merná jednotka: 1 * 100 µG

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Katalógové číslo: (USBIL1669-01S)

Dodávateľ: UNITED BIOCHEMICALS

Opis: Anti-LEP Rabbit Polyclonal Antibody

Merná jednotka: 1 * 250 µG

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Katalógové číslo: (USBI037738-PE)

Dodávateľ: UNITED BIOCHEMICALS

Opis: Anti-LEP Rabbit Polyclonal Antibody (PE (Phycoerythrin))

Merná jednotka: 1 * 200 µl

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Dodávateľ: CAYMAN

Opis: A number of tumor cells and cell lines have been observed to have highly upregulated expression and activity of fatty acid synthase (FAS). Inhibition of FAS by the irreversible inhibitor cerulenin leads to cytotoxicity and apoptosis in human cancer cell lines, an effect believed to be mediated by the accumulation of malonyl-coenzyme A in cells with an upregulated FAS pathway. Cerulenin also leads to profound weight loss and feeding inhibition in both high-fat diet wild type obese and leptin-deficient ob/ob mice.

Dodávateľ: CAYMAN

Opis: Thiazolidinediones (TZDs) are a group of structurally related peroxisome proliferator-activated receptor γ (PPARγ) agonists with antidiabetic actions <italic>in vivo</italic>. Rosiglitazone is a prototypical TZD and has served as a reference compound for this class. Rosiglitazone is a potent and selective PPARγ ligand. It binds to the PPARγ ligand-binding domain with a Kd of 43 nM. It activates luciferase-based expression constructs PPARγ1 and PPARγ2 with EC₅₀ values of approximately 30 nM and 100 nM, respectively. Rosiglitazone is active <italic>in vivo</italic> as an antidiabetic agent in the <italic>ob/ob</italic> mouse model, and has been used as an oral hypoglycemic agent in the treatment of Type II diabetes in humans for many years.

Katalógové číslo: (USBIC0107-09A)

Dodávateľ: UNITED BIOCHEMICALS

Opis: Anti-CDH11 Goat Polyclonal Antibody

Merná jednotka: 1 * 100 µG

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Katalógové číslo: (USBIL1670-07X)

Dodávateľ: UNITED BIOCHEMICALS

Opis: Anti-LEP Rabbit Polyclonal Antibody

Merná jednotka: 1 * 50 µl

Predaj

Katalógové číslo: (BOSSBS-11536R-A488)

Dodávateľ: BIOSS INC

Opis: In contrast to the rapid early-onset weight gain seen in ob/ob mice (1-3), mutations in the tub gene lead to obesity gradually and strongly resemble late-onset obesity as seen in the human population (4). In addition to excessive deposition of adipose tissue, mice with the tub phenotype also suffer retinal degeneration and neurosensory hearing loss (4-6). The tripartite character of tubby phenotype is strikingly similar to human obesity syndromes such as Alstr鰉 (5) and Bardet-Biedl (6). A candidate for the tub gene has been described (4). A G芓 transversion in this candidate gene eliminates a donor splice site in the 3' coding region resulting in a larger transcript containing an unspliced intron (4). A second prematurely truncated mRNA transcript with the unspliced intron was found to be expressed in the brains of tubby mice at a 2-3 fold higher rate as compared to B6 mice (4). It has been postulated that the phenotypic features of tubby mice can be attributed to cellular apoptosis triggered by the expression of a mutated tub gene (4).

Merná jednotka: 1 * 100 µl

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Katalógové číslo: (BOSSBS-11536R-A680)

Dodávateľ: BIOSS INC

Opis: In contrast to the rapid early-onset weight gain seen in ob/ob mice, mutations in the tub gene lead to obesity gradually and strongly resemble late-onset obesity as seen in the human population. In addition to excessive deposition of adipose tissue, mice with the tub phenotype also suffer retinal degeneration and neurosensory hearing loss. The tripartite character of tubby phenotype is strikingly similar to human obesity syndromes such as Alstr and Bardet-Biedl. A candidate for the tub gene has been described. A G - transversion in this candidate gene eliminates a donor splice site in the 3' coding region resulting in a larger transcript containing an unspliced intron. A second prematurely truncated mRNA transcript with the unspliced intron was found to be expressed in the brains of tubby mice at a 2-3 fold higher rate as compared to B6 mice. It has been postulated that the phenotypic features of tubby mice can be attributed to cellular apoptosis triggered by the expression of a mutated tub gene.

Merná jednotka: 1 * 100 µl

Predaj

Katalógové číslo: (BOSSBS-11536R-CY3)

Dodávateľ: BIOSS INC

Opis: In contrast to the rapid early-onset weight gain seen in ob/ob mice (1-3), mutations in the tub gene lead to obesity gradually and strongly resemble late-onset obesity as seen in the human population (4). In addition to excessive deposition of adipose tissue, mice with the tub phenotype also suffer retinal degeneration and neurosensory hearing loss (4-6). The tripartite character of tubby phenotype is strikingly similar to human obesity syndromes such as Alstr鰉 (5) and Bardet-Biedl (6). A candidate for the tub gene has been described (4). A G芓 transversion in this candidate gene eliminates a donor splice site in the 3' coding region resulting in a larger transcript containing an unspliced intron (4). A second prematurely truncated mRNA transcript with the unspliced intron was found to be expressed in the brains of tubby mice at a 2-3 fold higher rate as compared to B6 mice (4). It has been postulated that the phenotypic features of tubby mice can be attributed to cellular apoptosis triggered by the expression of a mutated tub gene (4).

Merná jednotka: 1 * 100 µl

Predaj

Katalógové číslo: (BOSSBS-11536R)

Dodávateľ: BIOSS INC

Opis: In contrast to the rapid early-onset weight gain seen in ob/ob mice (1-3), mutations in the tub gene lead to obesity gradually and strongly resemble late-onset obesity as seen in the human population (4). In addition to excessive deposition of adipose tissue, mice with the tub phenotype also suffer retinal degeneration and neurosensory hearing loss (4-6). The tripartite character of tubby phenotype is strikingly similar to human obesity syndromes such as Alstr鰉 (5) and Bardet-Biedl (6). A candidate for the tub gene has been described (4). A G芓 transversion in this candidate gene eliminates a donor splice site in the 3' coding region resulting in a larger transcript containing an unspliced intron (4). A second prematurely truncated mRNA transcript with the unspliced intron was found to be expressed in the brains of tubby mice at a 2-3 fold higher rate as compared to B6 mice (4). It has been postulated that the phenotypic features of tubby mice can be attributed to cellular apoptosis triggered by the expression of a mutated tub gene (4).

Merná jednotka: 1 * 100 µl

Predaj

Katalógové číslo: (BOSSBS-11536R-A647)

Dodávateľ: BIOSS INC

Opis: In contrast to the rapid early-onset weight gain seen in ob/ob mice (1-3), mutations in the tub gene lead to obesity gradually and strongly resemble late-onset obesity as seen in the human population (4). In addition to excessive deposition of adipose tissue, mice with the tub phenotype also suffer retinal degeneration and neurosensory hearing loss (4-6). The tripartite character of tubby phenotype is strikingly similar to human obesity syndromes such as Alstr鰉 (5) and Bardet-Biedl (6). A candidate for the tub gene has been described (4). A G芓 transversion in this candidate gene eliminates a donor splice site in the 3' coding region resulting in a larger transcript containing an unspliced intron (4). A second prematurely truncated mRNA transcript with the unspliced intron was found to be expressed in the brains of tubby mice at a 2-3 fold higher rate as compared to B6 mice (4). It has been postulated that the phenotypic features of tubby mice can be attributed to cellular apoptosis triggered by the expression of a mutated tub gene (4).

Merná jednotka: 1 * 100 µl

Predaj

Katalógové číslo: (BOSSBS-11536R-A350)

Dodávateľ: BIOSS INC

Opis: In contrast to the rapid early-onset weight gain seen in ob/ob mice (1-3), mutations in the tub gene lead to obesity gradually and strongly resemble late-onset obesity as seen in the human population (4). In addition to excessive deposition of adipose tissue, mice with the tub phenotype also suffer retinal degeneration and neurosensory hearing loss (4-6). The tripartite character of tubby phenotype is strikingly similar to human obesity syndromes such as Alstr鰉 (5) and Bardet-Biedl (6). A candidate for the tub gene has been described (4). A G芓 transversion in this candidate gene eliminates a donor splice site in the 3' coding region resulting in a larger transcript containing an unspliced intron (4). A second prematurely truncated mRNA transcript with the unspliced intron was found to be expressed in the brains of tubby mice at a 2-3 fold higher rate as compared to B6 mice (4). It has been postulated that the phenotypic features of tubby mice can be attributed to cellular apoptosis triggered by the expression of a mutated tub gene (4).

Merná jednotka: 1 * 100 µl

Predaj

Katalógové číslo: (USBI045003)

Dodávateľ: UNITED BIOCHEMICALS

Opis: Anti-LEP Rabbit Polyclonal Antibody (Biotin)

Merná jednotka: 1 * 50 µG

Predaj

Katalógové číslo: (ROCK110-401-320)

Dodávateľ: ROCKLAND

Opis: This antiserum against Mouse Leptin has been tested for use in ELISA and immunoblotting.  Reactivity in other immunoassays is unknown.  Obesity associated leptin is the product of the OB gene and has been identified with Type II diabetes.

Merná jednotka: 1 * 1 mL

Predaj

Katalógové číslo: (BOSSBS-11536R-CY7)

Dodávateľ: BIOSS INC

Opis: In contrast to the rapid early-onset weight gain seen in ob/ob mice (1-3), mutations in the tub gene lead to obesity gradually and strongly resemble late-onset obesity as seen in the human population (4). In addition to excessive deposition of adipose tissue, mice with the tub phenotype also suffer retinal degeneration and neurosensory hearing loss (4-6). The tripartite character of tubby phenotype is strikingly similar to human obesity syndromes such as Alstr鰉 (5) and Bardet-Biedl (6). A candidate for the tub gene has been described (4). A G芓 transversion in this candidate gene eliminates a donor splice site in the 3' coding region resulting in a larger transcript containing an unspliced intron (4). A second prematurely truncated mRNA transcript with the unspliced intron was found to be expressed in the brains of tubby mice at a 2-3 fold higher rate as compared to B6 mice (4). It has been postulated that the phenotypic features of tubby mice can be attributed to cellular apoptosis triggered by the expression of a mutated tub gene (4).

Merná jednotka: 1 * 100 µl

Predaj