Hľadali ste: Mícha\u010Dky+magnetické

Opis: Saporin is a ribosome-inactivating protein (RIP) of type I. This monomeric RNA N-glycosidase purified from seeds of the plant Saponaria officinalis also known as Soapwort, is capable of specific depurination of eukaryotic ribosomes thus arresting protein synthesis. No ligand has been identified in saporin hence its inability to transverse the cell membrane. Due to its toxicity and stability of the structure, saporin has proven extremely useful for construction of immunotoxins.

Katalógové číslo: BSENPE-001-100

Merná jednotka: 1 * 100 µG

Dodávateľ: BIOSENSIS PTY

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Opis: TrkA is a member of the neurotrophic tyrosine kinase receptor family. It is a membrane-bound receptor that upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TrkA is required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). TrkA leads to cell differentiations and may play a role in specifying sensory neuron subtypes. It has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. SUBCELLULAR LOCATION: TrkA is a heavily glycosylated transmembrane protein and contains 13 potential N-linked glycosylation sites. The TrkA-Fc chimera has N-linked and may have O-linked oligosaccharides.

Katalógové číslo: BSENPE-1248-100

Merná jednotka: 1 * 100 µG

Dodávateľ: BIOSENSIS PTY

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Opis: Anti-LAMP1 Mouse T4 Antibody [clone: 5H6]

Katalógové číslo: BSENM-1690-100

Merná jednotka: 1 * 100 µG

Dodávateľ: BIOSENSIS PTY

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Opis: Anti-ALDOC Mouse T4 Antibody [clone: 4A9]

Katalógové číslo: BSENM-1693-100

Merná jednotka: 1 * 100 µG

Dodávateľ: BIOSENSIS PTY

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Opis: The Biosensis NGFR/p75^ECD Rapid™ enzyme-linked immunosorbent assay (ELISA) kit is a sandwich ELISA that allows the quantification of the extracellular domain (ECD) of human p75 neurotrophin receptor in less than four hours in urine only if used as directed.

Katalógové číslo: BSENBEK-2239-2P

Merná jednotka: 1 * 192 Tests

Dodávateľ: BIOSENSIS PTY

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Opis: FUNCTION: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. SUBCELLULAR LOCATION: Cytoplasm; cytosol. Cell membrane. Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components. ALTERNATIVE PRODUCTS: 8 named isoforms produced by alternative splicing. Additional isoforms seem to exist. Isoforms differ from each other by the presence or absence of up to 5 of the 15 exons. One of these optional exons contains the additional tau/MAP repeat. TISSUE SPECIFICITY: Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system. DEVELOPMENTAL STAGE: Four-repeat (type II) tau is expressed in an adult-specific manner and is not found in fetal brain, whereas three-repeat (type I) tau is found in both adult and fetal brain. DOMAIN: The tau/MAP repeat binds to tubulin. In Alzheimer disease, the neuronal cytoskeleton in the brain is progressively disrupted and replaced by tangles of paired helical filaments and straight filaments, mainly composed of hyperphosphorylated forms of Microtubule-associated protein Tau. Defects in Microtubule-associated protein Tau are a cause of frontotemporal dementia and parkinsonism linked to chromosome 17, as well as a number of other neurodegenerative diseases.

Katalógové číslo: BSENC-1691-100

Merná jednotka: 1 * 100 µl

Dodávateľ: BIOSENSIS PTY

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Opis: Peptide YY (PYY) is secreted from endocrine cells in the lower small intestine, colon and pancreas. PYY inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility (Ref: SWISS-Prot).

Katalógové číslo: BSENC-1536-100

Merná jednotka: 1 * 100 µl

Dodávateľ: BIOSENSIS PTY

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Opis: The Biosensis Multi-Neurotrophin Rapid™ Screening ELISA Kit has been designed to allow rapid screening and quantification of NGF, BDNF, NT3 and NT4/5 in cell culture supernatants, lysates and brain extracts only if used as directed.

Katalógové číslo: BSENBEK-2231

Merná jednotka: 1 * 192 Tests

Dodávateľ: BIOSENSIS PTY

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Opis: The oligomeric form of Amyloid Beta peptide (Aβ, 1- 42) has been closely linked to Alzheimer’s Disease. Several ELISAs targeting Aβ have been developed; however, these ELISAs are known to cross-react with Amyloid Beta precursor protein (APP) and are poorly characterised against monomeric and oligomeric forms of the peptide.

Katalógové číslo: BSENBEK-2215-1P

Merná jednotka: 1 * 96 Tests

Dodávateľ: BIOSENSIS PTY

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Opis: The Biosensis GDNF RapidTM enzyme-linked immunosorbent assay (ELISA) Kit is a sandwich ELISA that allows the quantification of GDNF in less than 4 hours in cell culture supernatants, cell lysates, and serum only if used as directed. Please refer to the kit protocol for specific use instructions for each substrate application, in particular rat serum samples.

Katalógové číslo: BSENBEK-2230-2P

Merná jednotka: 1 * 192 Tests

Dodávateľ: BIOSENSIS PTY

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Opis: TAR DNA-binding protein 43 (TDP43) is a DNA and RNA-binding protein which regulates transcription and splicing (ref: SWISSPROT).

Katalógové číslo: BSENM-1403-100

Merná jednotka: 1 * 100 µl

Dodávateľ: BIOSENSIS PTY

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Opis: SF3B4 is one of 8 subunits of splicing factor SF3B. SF3B4 is ubiquitously expressed in the nuclei of eukaryotic cells, although it migrates into the cytoplasm of dividing cells.

Katalógové číslo: BSENM-1576-100

Merná jednotka: 1 * 100 µG

Dodávateľ: BIOSENSIS PTY

Predaj

Opis: Peptide YY (PYY) is secreted from endocrine cells in the lower small intestine, colon and pancreas. PYY inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility (Ref: SWISS-Prot).

Katalógové číslo: BSENC-1539-100

Merná jednotka: 1 * 100 µl

Dodávateľ: BIOSENSIS PTY

Predaj

Opis: Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. The Spectrins form into dimers and further into tetramers of alpha and beta subunits (Ref: Entrez Gene). The alpha-II subunit is widely expressed in tissues but, in the nervous system, is found predominantly in neurons.

Katalógové číslo: BSENM-1575-100

Merná jednotka: 1 * 100 µG

Dodávateľ: BIOSENSIS PTY

Predaj

Opis: C-reactive protein has several roles associated with host defence such as; promoting agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. It can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. COFACTOR: Binds 2 calcium ions per subunit. C-reactive protein exists as a homopentamer. There are 2 alternatively spliced isoforms. C-reactive protein is found in plasma and its concentration increases greatly during acute phase response to tissue injury, infection or other inflammatory stimuli. It is induced by IL-1 and IL-6.

Katalógové číslo: BSENC-1509-100

Merná jednotka: 1 * 100 µl

Dodávateľ: BIOSENSIS PTY

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Opis: Fatty acid-binding protein, adipocyte (ALBP) is a lipid transport protein which binds long chain fatty acids and other hydrophobic ligands and delivers them to their receptors in the nucleus. ALBP is found in the cytoplasm and nucleus of adipocytes.

Katalógové číslo: BSENC-1527-100

Merná jednotka: 1 * 100 µl

Dodávateľ: BIOSENSIS PTY

Predaj