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Katalógové číslo: (PRSI48-826)

Dodávateľ: PROSCI

Opis: PLK, a Polo type protein kinase, has been shown to function in mitosis. The mRNA is absent or expressed at very low levels during the G1 phase, begins to reaccumulate during the S phase, and reaches maximal levels during the G2/M phase. PLK1 may participate in targeting MPF to the nucleus during prophase and in regulating mitotic spindle function. These functions, in addition to its expression in proliferating cells, suggest that PLK1 has a role in cancer progression.

Merná jednotka: 1 * 50 µG

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Dodávateľ: Portwest

Opis: This rugged polo shirt is made of a heavyweight polyester and cotton mix (65% polyester, 35% cotton) that is soft to touch and comfortable to wear.

Dodávateľ: Portwest

Opis: A classic version of a best selling, high-visibility short sleeved polo shirt, in 100% recycled polyester fabric.

Dodávateľ: FRISTADS KANSAS

Opis: Short sleeved shirt made of 50% Coolmax® Dacron fibre and 50% polyester. The fabric transports sweat away from the body and dries quickly. Ideal for outdoor activities and sports.

Dodávateľ: Portwest

Opis: This practical long sleeved polo shirt offers full upper body comfort for casual wear. Manufactured from 65% polyester and 35% cotton.

Dodávateľ: Portwest

Opis: Long sleeved polo shirts made of 55% cotton, 45% polyester. Cotton comfort fabric for ultimate durability, comfort and breathability. HiVisTex tape provides excellent visibility.

Katalógové číslo: (PRSIXPS-1022)

Dodávateľ: PROSCI

Opis: Considerable evidence indicates that a Polo-Like Kinase (PLK) plays an important role in cell cycle regulation. PLK is also required for bipolar spindle formation, activation of the anaphase-promoting complex/cyclosome, and cytokinesis. Recent work led to the identification of a PLKK that is thought to be responsible for activation of PLK. Recent work (Erikson, et al., 2004) has shown that PLKK is in turn activated by phosphorylation at three sites (Ser482, Ser486 and Ser490). Thus activation of PLK is thought to involve a kinase cascade involving the phosphorylation of Ser482,486,490 in PLKK.

Merná jednotka: 1 * 100 µl

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Katalógové číslo: (PRSI79-858)

Dodávateľ: PROSCI

Opis: The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase preferentially phosphorylates and inactivates cell division cycle 2 protein (CDC2), and thus negatively regulates cell cycle G2/M transition. This kinase is associated with the membrane throughout the cell cycle. Its activity is highly regulated during the cell cycle. Protein kinases AKT1/PKB and PLK (Polo-like kinase) have been shown to phosphorylate and regulate the activity of this kinase. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Merná jednotka: 1 * 100 µG

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Dodávateľ: Portwest

Opis: Anti-static ESD polo shirt offers all the comfort and protection. Fabrics used in the ESD range are strong and durable.

Dodávateľ: Portwest

Opis: Convenient for cooler weather, and ideal for workers in industries exposed to heat. The stylish design of the garment has a three-button placket, finished with a ribbed collar and cuffs.

Katalógové číslo: (PRSI50-249)

Dodávateľ: PROSCI

Opis: Polo-like kinases are important regulators of cell cycle progression. PLK1 is a highly conserved Ser/Thr kinase that has essential roles in the formation of mitotic bipolar spindles (van Vugt et al., 2004). Deregulated expression of PLK’s is detected in many types of cancer and associated with oncogenesis (Takei et al., 2005). It has been proposed that PLK1 function is altered at different stages of mitosis through consecutive phosphorylation events at Ser137 and Thr210 (van de Weerdt et al., 2005).

Merná jednotka: 1 * 100 µl

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Dodávateľ: Portwest

Opis: This style combines all the benefits of the best selling long sleeve polo with the additional feature of two-toning for even more practical benefit. The polyester bird eye knit material used is breathable, light, and comfortable.

Dodávateľ: SIOEN

Opis: This lightweight soft shirt is made of 54,5% modacrylic, 44,5% cotton and 1% AST. It is flame retardant, anti-static, moisture-regulating and antibacterial.

Katalógové číslo: (PRSI5117)

Dodávateľ: PROSCI

Opis: Bora Antibody: Bora (Protein aurora borealis) is a key activator of Aurora Related Protein Kinase A (ARK-1), which is a centrosome-associated serine/threonine kinase that regulates centrosome maturation, bipolar spindle assembly and chromosome segregation during mitosis. Bora is localized to the nucleus until mitosis is initiated, then translocates to the cytoplasm in a Cdc2 dependent manner. Activation of Cdc2 initiates the release of Bora into the cytoplasm where it can bind and activate ARK-1. PLK1 (polo-like kinase-1) interacts with Bora to control the accessibility of its activation loop for phosphorylation and activation by ARK-1. Bora and ARK-1 cooperatively activate PLK1 and control mitotic entry. Bora mutants result in multipolar spindles in mitosis identical to those observed when ARK-1 function is blocked. Thus, the ARK1-Bora-PLK1 regulatory circuit in mammalian cells elucidates a key mechanism in cell cycle regulation. At least three isoforms of Bora are known to exist.

Merná jednotka: 1 * 100 µG

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Dodávateľ: Portwest

Opis: Beautifully fitted and ideal for personalisation, this essential women's style meets all workwear needs.

Katalógové číslo: (PRSI5107)

Dodávateľ: PROSCI

Opis: Bora Antibody: Bora (Protein aurora borealis) is a key activator of Aurora Related Protein Kinase A (ARK-1), which is a centrosome-associated serine/threonine kinase that regulates centrosome maturation, bipolar spindle assembly and chromosome segregation during mitosis. Bora is localized to the nucleus until mitosis is initiated, then translocates to the cytoplasm in a Cdc2 dependent manner. Activation of Cdc2 initiates the release of Bora into the cytoplasm where it can bind and activate ARK-1. PLK1 (polo-like kinase-1) interacts with Bora to control the accessibility of its activation loop for phosphorylation and activation by ARK-1. Bora and ARK-1 cooperatively activate PLK1 and control mitotic entry. Bora mutants result in multipolar spindles in mitosis identical to those observed when ARK-1 function is blocked. Thus, the ARK1-Bora-PLK1 regulatory circuit in mammalian cells elucidates a key mechanism in cell cycle regulation. At least three isoforms of Bora are known to exist.

Merná jednotka: 1 * 100 µG

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