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Image Unavailable-BOSSBS-9634R-A555

Anti-IDH1 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Katalógové číslo: (BOSSBS-9634R-A555)
Dodávateľ: BIOSS INC
Opis: The Isocitrate dehydrogenase cytoplasmic enzyme is a homodimer of 416 residues that belongs to the isocitrate and isopropylmalate dehydrogenases family. IDHC catalyzes the third step of the citric acid cycle, which involves the oxidative decarboxylation of isocitrate, forming ?ketoglutarate and CO2 in a two step reaction. The first step involves the oxidation of isocitrate to the intermediate oxalosuccinate, while the second step involves the production of ?ketoglutarate. During this process, either NADH or NADPH is produced along with CO2. Ca2+ can bind to IDHC as a complex with isocitrate, acting as a competitive inhibitor of Mg2+. The IDHC enzyme is inactivated by phosphorylation at Ser-113 and contains a clasp-like domain wherein both polypeptide chains in the dimer interlock. IDHC is expressed in a wide range of species and also in organisms that lack a complete citric acid cycle.
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-9095R-CY5.5

Anti-AGXT2L2 Rabbit Polyclonal Antibody (Cy5.5®)

Katalógové číslo: (BOSSBS-9095R-CY5.5)
Dodávateľ: BIOSS INC
Opis: Members of the class-III pyridoxal-phosphate-dependent aminotransferase family, such as AGXT2, catalyze the conversion of glyoxylate to glycine using L-alanine as the amino donor. AGXT2 protects from asymmetric dimethylarginine (ADMA)-induced inhibition in nitric oxide (NO) production. Elevated blood concentrations of ADMA, a methyl derivate of the amino acid arginine and an endogenous inhibitor of nitric oxide (NO) synthase, is produced by the physiological degradation of methylated proteins and is found in association with diabetes, hypertension, congestive heart failure and atherosclerosis. AGXT2L2 (alanine-glyoxylate aminotransferase 2-like 2) is a 450 amino acid pyridoxal phosphate that exists as a homotetramer. Belonging to the class-III pyridoxal-phosphate-dependent aminotransferase family, AGXT2L2 localizes to the mitochondria and exists as three alternatively spliced isoforms. Encoded by a gene located on human chromosome 5q35.3, AGXT2L2 may have similar functions as AGXT2.
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-12927R

Anti-CYP20A1 Rabbit Polyclonal Antibody

Katalógové číslo: (BOSSBS-12927R)
Dodávateľ: BIOSS INC
Opis: Cytochrome P450 proteins are heme-thiolate monooxygenases that mediate NADPH-dependent electron transport and function to oxidize a variety of structurally unrelated compounds, including steroids, fatty acids and xenobiotics. Specifically, Cytochrome P450s are responsible for metabolizing arachidonic acid to hydroxyeicosatetraenoic acid (a regulator of blood pressure) and epoxyeicosatrienoic acid (a molecule involved in signaling events). CYP20A1 (cytochrome P450, family 20, subfamily A, polypeptide 1), also known as CYP-M, is a 462 amino acid single-pass membrane protein that belongs to the cytochrome P450 family. CYP20A1 is thought to carry its own oxygen as it lacks a conserved I-helix motif and one amino acid of its conserved heme binding site.
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-10150R-HRP

Anti-ACADL Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Katalógové číslo: (BOSSBS-10150R-HRP)
Dodávateľ: BIOSS INC
Opis: The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family, which is a family of mitochondrial flavoenzymes involved in fatty acid and branched chain amino-acid metabolism. This protein is one of the four enzymes that catalyze the initial step of mitochondrial beta-oxidation of straight-chain fatty acid. Defects in this gene are the cause of long-chain acyl-CoA dehydrogenase (LCAD) deficiency, leading to nonketotic hypoglycemia. [provided by RefSeq].
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-5015R-A488

Anti-ACADL Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Katalógové číslo: (BOSSBS-5015R-A488)
Dodávateľ: BIOSS INC
Opis: The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family, which is a family of mitochondrial flavoenzymes involved in fatty acid and branched chain amino-acid metabolism. This protein is one of the four enzymes that catalyze the initial step of mitochondrial beta-oxidation of straight-chain fatty acid. Defects in this gene are the cause of long-chain acyl-CoA dehydrogenase (LCAD) deficiency, leading to nonketotic hypoglycemia. [provided by RefSeq].
Merná jednotka: 1 * 100 µl
Image Unavailable-ENZOALX400003G025

Diethyldithiokarbamát sodný trihydrát ≥99% (by titrimetric analysis)

Katalógové číslo: (ENZOALX400003G025)
Dodávateľ: ENZO LIFE SCIENCES
Opis: Nitric oxide (NO) spin-trapping reagent. Thiol and iron chelator. Inhibits induction of macrophage nitric oxide synthase (NOS). Has been shown to be an inhibitor of the nuclear transcription factor κB (NF-κB).
Merná jednotka: 1 * 25 g

New Product


Image Unavailable-CAYM21880-50

Ricobendazole ≥98%

Dodávateľ: CAYMAN
Opis: Ricobendazole, also known as albendazole sulfate, is a benzimidazole agent that inhibits tubulin polymerization and is commonly used as an antihelmintic and antiparasitic agent, with IC90 values ranging from 3.8 x 10-2 to <10-4 µg/ml against Encephalitozoon species.

Image Unavailable-BOSSBS-5983R-A350

Anti-APEH Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Katalógové číslo: (BOSSBS-5983R-A350)
Dodávateľ: BIOSS INC
Opis: AARE (Acylamino-acid-releasing enzyme) is also known as Acyl-peptide hydrolase. It catalyzes the hydrolysis of the terminal acetylated amino acid preferentially from small acetylated peptides. The acetyl amino acid formed by this hydrolase is further processed to acetate and a free amino acid by an aminoacylase. It can play an important role in destroying oxidatively damaged proteins in living cells. Deletions of this gene locus corresponding to the protein are found in various types of carcinomas, including small cell lung carcinoma and renal cell carcinoma.
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-4192R-A488

Anti-SLC25A20 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Katalógové číslo: (BOSSBS-4192R-A488)
Dodávateľ: BIOSS INC
Opis: SLC25A20 is one of several closely related mitochondrial membrane carrier proteins that shuttle substrates between cytosol and the intramitochondrial matrix space. It mediates the transport of acylcarnitines into the mitochondrial matrix for their oxidation by the mitochondrial fatty acid oxidation pathway. Mutations in this gene are associated with carnitine acylcarnitine translocase deficiency, which can cause a variety of pathological conditions such as hypoglycemia, cardiac arrest, hepatomegaly, hepatic dysfunction and muscle weakness, and is usually lethal in new born and infants.
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-0250R-CY5.5

Anti-PPARD Rabbit Polyclonal Antibody (Cy5.5®)

Katalógové číslo: (BOSSBS-0250R-CY5.5)
Dodávateľ: BIOSS INC
Opis: Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand (By similarity).
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-8339R-CY3

Anti-PANK3 Rabbit Polyclonal Antibody (Cy3®)

Katalógové číslo: (BOSSBS-8339R-CY3)
Dodávateľ: BIOSS INC
Opis: The pantothenate kinase (PANK) family of proteins catalyzes the first step in coenzyme A (CoA) biosynthesis. Coenzyme A is an important coenzyme involved in the synthesis and oxidation of fatty acids, as well as the oxidation of pyruvate in the citric acid (Krebs) cycle. Pantothenate kinase 3 (PANK3) is a 370 amino acid member of the pantothenate kinase family that plays a role in the physiological regulation of the intracellular CoA concentration. Localized to the cytoplasm, PANK3 is regulated by feedback inhibition by CoA and its thioesters. PANK3 transfers a phosphate from ATP to pantothenate (Vitamin B5), resulting in formation of 4’-phosphopantothenate. Closely related to its family members, PANK1, PANK2 and PANK4, PANK3 is highly expressed in liver. Pantothenate kinase associated neurodegeneration (PKAN) results from mutations in the gene encoding PANK2, the only mitochondria targeted human PANK.
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-8339R-CY7

Anti-PANK3 Rabbit Polyclonal Antibody (Cy7®)

Katalógové číslo: (BOSSBS-8339R-CY7)
Dodávateľ: BIOSS INC
Opis: The pantothenate kinase (PANK) family of proteins catalyzes the first step in coenzyme A (CoA) biosynthesis. Coenzyme A is an important coenzyme involved in the synthesis and oxidation of fatty acids, as well as the oxidation of pyruvate in the citric acid (Krebs) cycle. Pantothenate kinase 3 (PANK3) is a 370 amino acid member of the pantothenate kinase family that plays a role in the physiological regulation of the intracellular CoA concentration. Localized to the cytoplasm, PANK3 is regulated by feedback inhibition by CoA and its thioesters. PANK3 transfers a phosphate from ATP to pantothenate (Vitamin B5), resulting in formation of 4’-phosphopantothenate. Closely related to its family members, PANK1, PANK2 and PANK4, PANK3 is highly expressed in liver. Pantothenate kinase associated neurodegeneration (PKAN) results from mutations in the gene encoding PANK2, the only mitochondria targeted human PANK.
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-11997R

Anti-DDAH1 Rabbit Polyclonal Antibody

Katalógové číslo: (BOSSBS-11997R)
Dodávateľ: BIOSS INC
Opis: DDAH, a dimethylarginine dimethylaminohydrolase, hydrolyzes dimethyl arginine (ADMA) and monomethyl arginine (MMA), both inhibitors of nitric oxide synthases, and may be involved in in-vivo modulation of nitric oxide production (1,2). Impairment of DDAH causes ADMA accumulation and a reduction in cGMP generation (3). DDAH II, the predominant DDAH isoform in endothelial cells, facilitates the induction of nitric oxide synthesis by all-trans-Retinoic acid (atRA) (4). DDAH proteins are highly expressed in colon, kidney, stomach and liver tissues (1).
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-11997R-A750

Anti-DDAH1 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Katalógové číslo: (BOSSBS-11997R-A750)
Dodávateľ: BIOSS INC
Opis: DDAH, a dimethylarginine dimethylaminohydrolase, hydrolyses dimethyl arginine (ADMA) and monomethyl arginine (MMA), both inhibitors of nitric oxide synthases, and may be involved in in-vivo modulation of nitric oxide production. Impairment of DDAH causes ADMA accumulation and a reduction in cGMP generation. DDAH II, the predominant DDAH isoform in endothelial cells, facilitates the induction of nitric oxide synthesis by all-trans-Retinoic acid (atRA) (4). DDAH proteins are highly expressed in colon, kidney, stomach and liver tissues.
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-11797R-A350

Anti-ALDH3A2 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Katalógové číslo: (BOSSBS-11797R-A350)
Dodávateľ: BIOSS INC
Opis: Aldehyde dehydrogenases (ALDHs) mediate the NADP+-dependent oxidation of aldehydes into acids and play an important role in the detoxification of alcohol-derived acetaldehyde, as well as in lipid peroxidation and in the metabolism of corticosteroids, biogenic amines and neurotransmitters. ALDH3A2 (aldehyde dehydrogenase 3 family, member A2), also known as SLS, FALDH or ALDH10, is a 485 amino acid single-pass membrane protein that localizes to the cytoplasmic side of the endoplasmic reticulum and belongs to the aldehyde dehydrogenase family. Expressed in a variety of tissues, including liver, heart, lung, brain, kidney and placenta, ALDH3A2 catalyzes the NAD+-dependent oxidation of long-chain aliphatic aldehydes to fatty acids, a process that is necessary for detoxification and lipid metabolism. Defects in the gene encoding ALDH3A2 are the cause of Sjoegren-Larsson syndrome (SLS), an autosomal recessive neurocutaneous disorder characterized by severe mental retardation, seizures and speech defects. Multiple isoforms of ALDH3A2 exist due to alternative splicing events.
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-2352R-A555

Anti-CYP2B6 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Katalógové číslo: (BOSSBS-2352R-A555)
Dodávateľ: BIOSS INC
Opis: Cytochromes P45 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Merná jednotka: 1 * 100 µl
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