Tlačiť

Hľadali ste: Picolinic+acid+N-oxide


111 317  results were found

Spresniť výsledky Zoradiť podľa
SearchResultCount:"111317"

Sort Results

Zobraziť zoznam Easy View (Nové)

Ohodnotiť tieto výsledky vyhľadávania

Image Unavailable-BOSSBS-8300R-A750

Anti-Peroxiredoxin 2 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Katalógové číslo: (BOSSBS-8300R-A750)
Dodávateľ: BIOSS INC
Opis: Peroxiredoxin (Prx) is an antioxidant enzyme detoxifying reactive oxygen species and has a cysteine at the active site. Prx enzymes modulate various receptor signaling pathways and protect cells from oxidatively induced death. Peroxiredoxin 1 to 4 have two conserved Cys residues corresponding to Cys51 and Cys172 of mammalian Peroxiredoxin 1. The active site cysteine(Cys51) is oxidised to cysteine sulfenic acid(Cys51-SOH) when a peroxide is reduced. Because Cys51-SOH is unstable, it forms a disulfide with Cys172-SH which comes from the other subunit of the homodimer. The disulfide is then reduced back to the Prx active thiol form by the thioredoxin-thioredoxin reductase system. However, the formation of the disulfide is a slow process. Thus under oxidative stress conditions, the sulfenic intermediate(Cys51-SOH) can be easily over oxidised to cysteine sulfinic acid(Cys-SO2H) or cysteine sulfonic acid(Cys-SO3H) before it is able to form a disulfide. Recent studies suggest that over oxidised Prx can be reduced back to the active form during recovery after oxidative stress.
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-9634R

Anti-IDH1 Rabbit Polyclonal Antibody

Katalógové číslo: (BOSSBS-9634R)
Dodávateľ: BIOSS INC
Opis: The Isocitrate dehydrogenase cytoplasmic enzyme is a homodimer of 416 residues that belongs to the isocitrate and isopropylmalate dehydrogenases family. IDHC catalyzes the third step of the citric acid cycle, which involves the oxidative decarboxylation of isocitrate, forming ?ketoglutarate and CO2 in a two step reaction. The first step involves the oxidation of isocitrate to the intermediate oxalosuccinate, while the second step involves the production of ?ketoglutarate. During this process, either NADH or NADPH is produced along with CO2. Ca2+ can bind to IDHC as a complex with isocitrate, acting as a competitive inhibitor of Mg2+. The IDHC enzyme is inactivated by phosphorylation at Ser-113 and contains a clasp-like domain wherein both polypeptide chains in the dimer interlock. IDHC is expressed in a wide range of species and also in organisms that lack a complete citric acid cycle.
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-9634R-CY7

Anti-IDH1 Rabbit Polyclonal Antibody (Cy7®)

Katalógové číslo: (BOSSBS-9634R-CY7)
Dodávateľ: BIOSS INC
Opis: The Isocitrate dehydrogenase cytoplasmic enzyme is a homodimer of 416 residues that belongs to the isocitrate and isopropylmalate dehydrogenases family. IDHC catalyzes the third step of the citric acid cycle, which involves the oxidative decarboxylation of isocitrate, forming ?ketoglutarate and CO2 in a two step reaction. The first step involves the oxidation of isocitrate to the intermediate oxalosuccinate, while the second step involves the production of ?ketoglutarate. During this process, either NADH or NADPH is produced along with CO2. Ca2+ can bind to IDHC as a complex with isocitrate, acting as a competitive inhibitor of Mg2+. The IDHC enzyme is inactivated by phosphorylation at Ser-113 and contains a clasp-like domain wherein both polypeptide chains in the dimer interlock. IDHC is expressed in a wide range of species and also in organisms that lack a complete citric acid cycle.
Merná jednotka: 1 * 100 µl
Product Image-BOSSBS-2888R

Anti-TRPM2 Rabbit Polyclonal Antibody

Katalógové číslo: (BOSSBS-2888R)
Dodávateľ: BIOSS INC
Opis: Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has ADP-ribose pyrophosphatase activity.
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-1603R-A647

Anti-AARS2 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Katalógové číslo: (BOSSBS-1603R-A647)
Dodávateľ: BIOSS INC
Opis: The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. Aminoacyl-tRNA synthetases play critical roles in mRNA translation by charging tRNAs with their cognate amino acids. The encoded protein is a mitochondrial enzyme that specifically aminoacylates alanyl-tRNA. Mutations in this gene are a cause of combined oxidative phosphorylation deficiency 8.
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-1603R-A350

Anti-AARS2 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Katalógové číslo: (BOSSBS-1603R-A350)
Dodávateľ: BIOSS INC
Opis: The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. Aminoacyl-tRNA synthetases play critical roles in mRNA translation by charging tRNAs with their cognate amino acids. The encoded protein is a mitochondrial enzyme that specifically aminoacylates alanyl-tRNA. Mutations in this gene are a cause of combined oxidative phosphorylation deficiency 8.
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-12927R

Anti-CYP20A1 Rabbit Polyclonal Antibody

Katalógové číslo: (BOSSBS-12927R)
Dodávateľ: BIOSS INC
Opis: Cytochrome P450 proteins are heme-thiolate monooxygenases that mediate NADPH-dependent electron transport and function to oxidize a variety of structurally unrelated compounds, including steroids, fatty acids and xenobiotics. Specifically, Cytochrome P450s are responsible for metabolizing arachidonic acid to hydroxyeicosatetraenoic acid (a regulator of blood pressure) and epoxyeicosatrienoic acid (a molecule involved in signaling events). CYP20A1 (cytochrome P450, family 20, subfamily A, polypeptide 1), also known as CYP-M, is a 462 amino acid single-pass membrane protein that belongs to the cytochrome P450 family. CYP20A1 is thought to carry its own oxygen as it lacks a conserved I-helix motif and one amino acid of its conserved heme binding site.
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-4047R-A488

Anti-ACADM Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Katalógové číslo: (BOSSBS-4047R-A488)
Dodávateľ: BIOSS INC
Opis: ACADM protein is a medium chain specific (C4 to C12 straight chain) acyl Coenzyme A dehydrogenase. The enzyme catalyzes the initial step of the mitochondrial fatty acid beta oxidation pathway. ACADM expression is induced during periods of fasting, when reliance on fatty acids for energy is increased. Clinical phenotypes are associated with ACADM hereditary deficiency.
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-5058R-A750

Anti-ECHS1 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Katalógové číslo: (BOSSBS-5058R-A750)
Dodávateľ: BIOSS INC
Opis: ECHS1 (Enoyl Coenzyme A hydratase, short chain, 1) catalyses the hydration of 2-trans-enoyl-coenzyme A (CoA) intermediates to L-3-hydroxyacyl-CoAs, in the second step of the mitochondrial fatty acid beta-oxidation pathway.
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-10255R-FITC

Anti-L-Citrulline Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Katalógové číslo: (BOSSBS-10255R-FITC)
Dodávateľ: BIOSS INC
Opis: The amino acid Citrulline is required to detoxify the liver from ammonia, which is a waste product of the body from oxidation. Citrulline promotes energy and assists with the immune system. This unusual amino acid is formed in the urea cycle by the addition of carbon dioxide and ammonia to ornithine. It is then combined with aspartic acid to form arginosuccinic acid, which later is metabolized into the amino acid arginine.
Merná jednotka: 1 * 100 µl
Image Unavailable-CAYM21880-5

Ricobendazole ≥98%

Dodávateľ: CAYMAN
Opis: Ricobendazole, also known as albendazole sulfate, is a benzimidazole agent that inhibits tubulin polymerization and is commonly used as an antihelmintic and antiparasitic agent, with IC90 values ranging from 3.8 x 10-2 to <10-4 µg/ml against Encephalitozoon species.

Image Unavailable-BOSSBS-4192R-CY3

Anti-SLC25A20 Rabbit Polyclonal Antibody (Cy3®)

Katalógové číslo: (BOSSBS-4192R-CY3)
Dodávateľ: BIOSS INC
Opis: SLC25A20 is one of several closely related mitochondrial membrane carrier proteins that shuttle substrates between cytosol and the intramitochondrial matrix space. It mediates the transport of acylcarnitines into the mitochondrial matrix for their oxidation by the mitochondrial fatty acid oxidation pathway. Mutations in this gene are associated with carnitine acylcarnitine translocase deficiency, which can cause a variety of pathological conditions such as hypoglycemia, cardiac arrest, hepatomegaly, hepatic dysfunction and muscle weakness, and is usually lethal in new born and infants.
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-12926R-A647

Anti-CYP1B1 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Katalógové číslo: (BOSSBS-12926R-A647)
Dodávateľ: BIOSS INC
Opis: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, retinoid and xenobiotics. Preferentially oxidizes 17beta-estradiol to the carcinogenic 4-hydroxy derivative, and a variety of procarcinogenic compounds to their activated forms, including polycyclic aromatic hydrocarbons. Promotes angiogenesis by removing cellular oxygenation products, thereby decreasing oxidative stress, release of antiangiogenic factor THBS2, then allowing endothelial cells migration, cell adhesion and capillary morphogenesis. These changes are concommitant with the endothelial nitric oxide synthase activity and nitric oxide synthesis. Plays an important role in the regulation of perivascular cell proliferation, migration, and survival through modulation of the intracellular oxidative state and NF-kappa-B expression and/or activity, during angiogenesis. Contributes to oxidative homeostasis and ultrastructural organization and function of trabecular meshwork tissue through modulation of POSTN expression.
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-4192R

Anti-SLC25A20 Rabbit Polyclonal Antibody

Katalógové číslo: (BOSSBS-4192R)
Dodávateľ: BIOSS INC
Opis: SLC25A20 is one of several closely related mitochondrial membrane carrier proteins that shuttle substrates between cytosol and the intramitochondrial matrix space. It mediates the transport of acylcarnitines into the mitochondrial matrix for their oxidation by the mitochondrial fatty acid oxidation pathway. Mutations in this gene are associated with carnitine acylcarnitine translocase deficiency, which can cause a variety of pathological conditions such as hypoglycemia, cardiac arrest, hepatomegaly, hepatic dysfunction and muscle weakness, and is usually lethal in new born and infants.
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-11997R-CY3

Anti-DDAH1 Rabbit Polyclonal Antibody (Cy3®)

Katalógové číslo: (BOSSBS-11997R-CY3)
Dodávateľ: BIOSS INC
Opis: DDAH, a dimethylarginine dimethylaminohydrolase, hydrolyzes dimethyl arginine (ADMA) and monomethyl arginine (MMA), both inhibitors of nitric oxide synthases, and may be involved in in-vivo modulation of nitric oxide production (1,2). Impairment of DDAH causes ADMA accumulation and a reduction in cGMP generation (3). DDAH II, the predominant DDAH isoform in endothelial cells, facilitates the induction of nitric oxide synthesis by all-trans-Retinoic acid (atRA) (4). DDAH proteins are highly expressed in colon, kidney, stomach and liver tissues (1).
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-11797R-CY5

Anti-ALDH3A2 Rabbit Polyclonal Antibody (Cy5®)

Katalógové číslo: (BOSSBS-11797R-CY5)
Dodávateľ: BIOSS INC
Opis: Aldehyde dehydrogenases (ALDHs) mediate the NADP+-dependent oxidation of aldehydes into acids and play an important role in the detoxification of alcohol-derived acetaldehyde, as well as in lipid peroxidation and in the metabolism of corticosteroids, biogenic amines and neurotransmitters. ALDH3A2 (aldehyde dehydrogenase 3 family, member A2), also known as SLS, FALDH or ALDH10, is a 485 amino acid single-pass membrane protein that localizes to the cytoplasmic side of the endoplasmic reticulum and belongs to the aldehyde dehydrogenase family. Expressed in a variety of tissues, including liver, heart, lung, brain, kidney and placenta, ALDH3A2 catalyzes the NAD+-dependent oxidation of long-chain aliphatic aldehydes to fatty acids, a process that is necessary for detoxification and lipid metabolism. Defects in the gene encoding ALDH3A2 are the cause of Sjoegren-Larsson syndrome (SLS), an autosomal recessive neurocutaneous disorder characterized by severe mental retardation, seizures and speech defects. Multiple isoforms of ALDH3A2 exist due to alternative splicing events.
Merná jednotka: 1 * 100 µl
Zavolať a opýtať sa na ceny
Zásoby tejto položky sú obmedzené, no môžu sa nachádzať v inom sklade blízko pri vás. Uistite sa prosím, že ste prihlásený/á na tejto lokalite, aby sa mohli zobraziť dostupné zásoby. Ak sa stále zobrazuje zavolajte a potrebujete pomoc, zavolajte nám prosím na číslo +43 1 97002 - 0.
Zásoby tejto položky sú obmedzené, no môžu sa nachádzať v inom sklade blízko pri vás. Uistite sa prosím, že ste prihlásený/á na tejto lokalite, aby sa mohli zobraziť dostupné zásoby. Ak sa stále zobrazuje zavolajte a potrebujete pomoc, zavolajte nám prosím na číslo +43 1 97002 - 0.
Daná chemikália je regulovaná podľa platnej legislatívy a bude vyžadované vyplnenie formulára. Jeho včasným vyplnením urýchlite dodanie produktu.
-Na zakúpenie tejto položky môže byť potrebná dodatočná dokumentácia. Ak to bude potrebné, skontaktuje sa s vami zástupca spoločnosti VWR.
Tento produkt bol zablokovaný vašou organizáciou. Kontaktujte prosím vaše oddelenie nákupu pre získanie viac informácií.
Pôvodný produkt už nie je dostupný. Je dostupná zobrazená náhrada.
Tento produkt už nie je dostupný. Môžu byť k dispozícii alternatívy, ktoré sa dajú vyhľadať pomocou katalógového čísla VWR uvedeného vyššie. Ak potrebujete ďalšiu pomoc, zavolajte prosím na zákaznícky servis spoločnosti VWR na čísle +43 1 97002 - 0.
353 - 368 of 111 317
no targeter for Bottom