Hľadali ste: N-Boc-L-serine

Katalógové číslo: (BOSSBS-3009R-HRP)

Dodávateľ: BIOSS INC

Opis: Bad is a member of the Bcl2 family and acts to promote apoptosis by forming heterodimers with the survival proteins Bcl2 and BclxL, thus preventing them from binding with BAX. Bad is found on the outer mitochondrial membrane and, once phosphorylated in response to growth stimuli, translocates to the cytoplasm. The phosphorylation status of Bad represents a key checkpoint for death or cell survival. JNK-induced phosphorylation of BAD serine 128 promotes the apoptotic role of Bad by opposing the inhibitory effect of growth factor on Bad-mediated apoptosis. Cdc2-induced phosphorylation of Bad serine 128 has an inhibitory effect on its interaction with 14-3-3 proteins. The latter interaction is critical for Bad phosphorylation at serine 155, a site within the BH3 domain that leads to the release of BclxL and the promotion of cell survival. Alternative splicing of this gene results in two transcript variants which encode the same isoform.

Merná jednotka: 1 * 100 µl

Predaj

Dodávateľ: ENZO LIFE SCIENCES

Opis: Glycogen Synthase Kinase 3β (GSK-3β) is a unique serine/threonine kinase that is inactivated by phosphorylation. In response to insulin binding, PKB/AKT phosphorylates GSK-3β on serine 9, which prevents GSK-3β from phosphorylating glycogen synthase. Unphosphorylated glycogen synthase is active and able to synthesize glycogen. GSK-3β is also unique in that it requires a substrate that has been phosphorylated by a distinct kinase before it can phosphorylate the substrate. This phosphate priming mechanism explains why phosphorylation of serine 9 inactivates GSK-3β. The phosphorylated serine binds to the GSK-3β priming phosphate position and prevents binding of alternative substrates. In addition to insulin signaling, GSK-3β participates in the Wnt signaling pathway, where it forms a complex with axin, beta-catenin and adenomatous polyposis coli (APC) protein. In the presence of Wnts, GSK-3β is unable to phosphorylate beta-catenin, which leads to stabilization of beta-catenin. The Wnt pathway inactivates GSK-3β via the proteins, Dishevelled and FRAT, which disrupt the interaction of GSK-3β with axin, beta-catenin, and APC. Clinically, there is considerable interest in GSK-3β inhibitors because they may mimic the effect of insulin or reduce the hyperphosphorylation of Tau that is observed in Alzheimer's Disease.

New Product

Katalógové číslo: (BOSSBS-9010R-CY5.5)

Dodávateľ: BIOSS INC

Opis: DPP6 is a Type-II serine proteinase of the clan SC. The clan SC proteinases have a catalytic triad of Ser-Asp-His, and like other Serine proteinases, the active site serine is in a Gly-Xaa-Ser-Xaa -Gly orientation. DPP6 has an Asp instead of Ser in the catalytic site. DPP6 is a member of a broader family of dipeptidyl peptidases including DPP4, FAP/Seprase, DPP2, DPP8, DPP9, DPP10, which have differing substrate specificity and tissue localizations. The surface-bound DPP6 is a homodimer, and cleavage of in the stalk region releases a shed form of DPP6. The shed is the form found in serum. DPP6 has been found in highest abundance in the brain, but also in the kidney, liver and lung.

Merná jednotka: 1 * 100 µl

Predaj

Katalógové číslo: (BOSSBS-9010R-A555)

Dodávateľ: BIOSS INC

Opis: DPP6 is a Type-II serine proteinase of the clan SC. The clan SC proteinases have a catalytic triad of Ser-Asp-His, and like other Serine proteinases, the active site serine is in a Gly-Xaa-Ser-Xaa -Gly orientation. DPP6 has an Asp instead of Ser in the catalytic site. DPP6 is a member of a broader family of dipeptidyl peptidases including DPP4, FAP/Seprase, DPP2, DPP8, DPP9, DPP10, which have differing substrate specificity and tissue localizations. The surface-bound DPP6 is a homodimer, and cleavage of in the stalk region releases a shed form of DPP6. The shed is the form found in serum. DPP6 has been found in highest abundance in the brain, but also in the kidney, liver and lung.

Merná jednotka: 1 * 100 µl

Predaj

Katalógové číslo: (BOSSBS-9010R-A647)

Dodávateľ: BIOSS INC

Opis: DPP6 is a Type-II serine proteinase of the clan SC. The clan SC proteinases have a catalytic triad of Ser-Asp-His, and like other Serine proteinases, the active site serine is in a Gly-Xaa-Ser-Xaa -Gly orientation. DPP6 has an Asp instead of Ser in the catalytic site. DPP6 is a member of a broader family of dipeptidyl peptidases including DPP4, FAP/Seprase, DPP2, DPP8, DPP9, DPP10, which have differing substrate specificity and tissue localizations. The surface-bound DPP6 is a homodimer, and cleavage of in the stalk region releases a shed form of DPP6. The shed is the form found in serum. DPP6 has been found in highest abundance in the brain, but also in the kidney, liver and lung.

Merná jednotka: 1 * 100 µl

Predaj

Katalógové číslo: (BOSSBS-9010R-CY5)

Dodávateľ: BIOSS INC

Opis: DPP6 is a Type-II serine proteinase of the clan SC. The clan SC proteinases have a catalytic triad of Ser-Asp-His, and like other Serine proteinases, the active site serine is in a Gly-Xaa-Ser-Xaa -Gly orientation. DPP6 has an Asp instead of Ser in the catalytic site. DPP6 is a member of a broader family of dipeptidyl peptidases including DPP4, FAP/Seprase, DPP2, DPP8, DPP9, DPP10, which have differing substrate specificity and tissue localizations. The surface-bound DPP6 is a homodimer, and cleavage of in the stalk region releases a shed form of DPP6. The shed is the form found in serum. DPP6 has been found in highest abundance in the brain, but also in the kidney, liver and lung.

Merná jednotka: 1 * 100 µl

Predaj

Katalógové číslo: (BOSSBS-5777R-A680)

Dodávateľ: BIOSS INC

Opis: Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.

Merná jednotka: 1 * 100 µl

Predaj

Katalógové číslo: (BWRLBS4673)

Dodávateľ: BIOWORLD TECHNOLOGY

Opis: Synthetic phosphopeptide derived from human Csk around the phosphorylation site of Serine 364.

Merná jednotka: 1 * 100 µG

Predaj

Katalógové číslo: (BWRLBS4839)

Dodávateľ: BIOWORLD TECHNOLOGY

Opis: Synthetic phosphopeptide derived from human c-Rel around the phosphorylation site of Serine 503.

Merná jednotka: 1 * 100 µG

Predaj

Katalógové číslo: (BWRLBS5027)

Dodávateľ: BIOWORLD TECHNOLOGY

Opis: Synthetic phosphopeptide derived from human p53 around the phosphorylation site of Serine 20.

Merná jednotka: 1 * 100 µG

Predaj

Katalógové číslo: (BWRLBS4879)

Dodávateľ: BIOWORLD TECHNOLOGY

Opis: Synthetic phosphopeptide derived from human Synapsin I around the phosphorylation site of Serine 62.

Merná jednotka: 1 * 100 µG

Predaj

Katalógové číslo: (BOSSBS-5777R-A750)

Dodávateľ: BIOSS INC

Opis: Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.

Merná jednotka: 1 * 100 µl

Predaj

Katalógové číslo: (BWRLBS4393)

Dodávateľ: BIOWORLD TECHNOLOGY

Opis: Synthetic phosphopeptide derived from human CREB around the phosphorylation site of Serine 121.

Merná jednotka: 1 * 100 µG

Predaj

Katalógové číslo: (BWRLBS4095)

Dodávateľ: BIOWORLD TECHNOLOGY

Opis: Synthetic phosphopeptide derived from human HSP27 around the phosphorylation site of Serine 15.

Merná jednotka: 1 * 100 µG

Predaj

Katalógové číslo: (BWRLBS4670)

Dodávateľ: BIOWORLD TECHNOLOGY

Opis: Synthetic phosphopeptide derived from human Chk1 around the phosphorylation site of Serine 286.

Merná jednotka: 1 * 100 µG

Predaj

Katalógové číslo: (BWRLAP0149)

Dodávateľ: BIOWORLD TECHNOLOGY

Opis: Synthetic phosphopeptide derived from human GFAP around the phosphorylation site of Serine 38.

Merná jednotka: 1 * 100 µG

Predaj