Hľadali ste: N-Boc-L-serine

Katalógové číslo: (BOSSBS-3524R-A750)

Dodávateľ: BIOSS INC

Opis: PED/PEA 15 (Phosphoprotein Enriched in Diabetes/Phosphoprotein Enriched in Astrocytes 15 kDa) is a widely expressed 15 kDa protein comprised of an N terminal region containing a canonical Death Effector Domain (DED) sequence and a nuclear export signal, and a C terminal region containing two serine phosphorylation sites. PED/PEA 15 has been implicated in the regulation of multiple cellular processes including apoptosis, integrin activation, and insulin sensitive glucose transport in insulin responsive cells. Phosphorylation of both serine 104 (a Protein Kinase C site) and serine 116 (a substrate of CaMKII and Akt) is required for PED/PEA 15 function.

Merná jednotka: 1 * 100 µl

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Katalógové číslo: (BOSSBS-3524R-A488)

Dodávateľ: BIOSS INC

Opis: PED/PEA 15 (Phosphoprotein Enriched in Diabetes/Phosphoprotein Enriched in Astrocytes 15 kDa) is a widely expressed 15 kDa protein comprised of an N terminal region containing a canonical Death Effector Domain (DED) sequence and a nuclear export signal, and a C terminal region containing two serine phosphorylation sites. PED/PEA 15 has been implicated in the regulation of multiple cellular processes including apoptosis, integrin activation, and insulin sensitive glucose transport in insulin responsive cells. Phosphorylation of both serine 104 (a Protein Kinase C site) and serine 116 (a substrate of CaMKII and Akt) is required for PED/PEA 15 function.

Merná jednotka: 1 * 100 µl

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Katalógové číslo: (BOSSBS-7918R-CY5.5)

Dodávateľ: BIOSS INC

Opis: PLK5 (Serine/threonine-protein kinase PLK5) belongs to the protein kinase superfamily and Ser/Thr protein kinase family and CDC5/Polo subfamily. PLK5P contains 1 POLO box domain and 1 Serine/Threonine protein kinase catalytic domain.

Merná jednotka: 1 * 100 µl

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Katalógové číslo: (BOSSBS-7918R-A488)

Dodávateľ: BIOSS INC

Opis: PLK5 (Serine/threonine-protein kinase PLK5) belongs to the protein kinase superfamily and Ser/Thr protein kinase family and CDC5/Polo subfamily. PLK5P contains 1 POLO box domain and 1 Serine/Threonine protein kinase catalytic domain.

Merná jednotka: 1 * 100 µl

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Katalógové číslo: (BOSSBS-7918R-A555)

Dodávateľ: BIOSS INC

Opis: PLK5 (Serine/threonine-protein kinase PLK5) belongs to the protein kinase superfamily and Ser/Thr protein kinase family and CDC5/Polo subfamily. PLK5P contains 1 POLO box domain and 1 Serine/Threonine protein kinase catalytic domain.

Merná jednotka: 1 * 100 µl

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Katalógové číslo: (BOSSBS-3009R-HRP)

Dodávateľ: BIOSS INC

Opis: Bad is a member of the Bcl2 family and acts to promote apoptosis by forming heterodimers with the survival proteins Bcl2 and BclxL, thus preventing them from binding with BAX. Bad is found on the outer mitochondrial membrane and, once phosphorylated in response to growth stimuli, translocates to the cytoplasm. The phosphorylation status of Bad represents a key checkpoint for death or cell survival. JNK-induced phosphorylation of BAD serine 128 promotes the apoptotic role of Bad by opposing the inhibitory effect of growth factor on Bad-mediated apoptosis. Cdc2-induced phosphorylation of Bad serine 128 has an inhibitory effect on its interaction with 14-3-3 proteins. The latter interaction is critical for Bad phosphorylation at serine 155, a site within the BH3 domain that leads to the release of BclxL and the promotion of cell survival. Alternative splicing of this gene results in two transcript variants which encode the same isoform.

Merná jednotka: 1 * 100 µl

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Katalógové číslo: (BOSSBS-9027R-A750)

Dodávateľ: BIOSS INC

Opis: This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I.

Merná jednotka: 1 * 100 µl

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Katalógové číslo: (BOSSBS-12373R)

Dodávateľ: BIOSS INC

Opis: The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/threonine (Ser/Thr) protein kinases. STK33 (serine/threonine kinase 33) is a 514 amino acid protein that belongs to the CaMK (calcium/calmodulin dependent kinase) subfamily of structurally related serine/threonine kinases. Widely expressed at low levels with predominant expression in testis, lung, retina and fetal organs such as brain, heart and spinal cord, STK33 contains one protein kinase domain and functions as a Ser/Thr protein kinase with a possible role in spermatogenesis. The gene encoding STK33 lies within a region on chromosome 11 that has been associated with a variety of defects, including Long QT syndrome, T-cell leukemia, Beckwith-Wiedemann syndrome, Usher syndrome 1C and various other malignancies.

Merná jednotka: 1 * 100 µl

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Dodávateľ: ENZO LIFE SCIENCES

Opis: Glycogen Synthase Kinase 3β (GSK-3β) is a unique serine/threonine kinase that is inactivated by phosphorylation. In response to insulin binding, PKB/AKT phosphorylates GSK-3β on serine 9, which prevents GSK-3β from phosphorylating glycogen synthase. Unphosphorylated glycogen synthase is active and able to synthesize glycogen. GSK-3β is also unique in that it requires a substrate that has been phosphorylated by a distinct kinase before it can phosphorylate the substrate. This phosphate priming mechanism explains why phosphorylation of serine 9 inactivates GSK-3β. The phosphorylated serine binds to the GSK-3β priming phosphate position and prevents binding of alternative substrates. In addition to insulin signaling, GSK-3β participates in the Wnt signaling pathway, where it forms a complex with axin, beta-catenin and adenomatous polyposis coli (APC) protein. In the presence of Wnts, GSK-3β is unable to phosphorylate beta-catenin, which leads to stabilization of beta-catenin. The Wnt pathway inactivates GSK-3β via the proteins, Dishevelled and FRAT, which disrupt the interaction of GSK-3β with axin, beta-catenin, and APC. Clinically, there is considerable interest in GSK-3β inhibitors because they may mimic the effect of insulin or reduce the hyperphosphorylation of Tau that is observed in Alzheimer's Disease.

New Product

Katalógové číslo: (BOSSBS-9213R-CY3)

Dodávateľ: BIOSS INC

Opis: The serine proteinase inhibitors (serpins) compose a superfamily of proteins with a diverse set of functions, including the control of blood coagulation, complement activation, programmed cell death and development. Serpins are secreted glycoproteins that contain a stretch of peptide that mimics a true substrate for a corresponding serine protease. SERPINB12 appears to be an inhibitor of trypsin-like serine proteinases, including mast cell tryptases.

Merná jednotka: 1 * 100 µl

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Katalógové číslo: (786-051)

Dodávateľ: G BIOSCIENCES

Opis: Leupeptin, hemisulphate inhibits serine, plasmin, porcine kallikrein and cysteine proteases, including papain and cathepsin B. Does not inhibit chymotrypsin and thrombin

Merná jednotka: 1 * 25 mg

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Katalógové číslo: (BWRLBS4854)

Dodávateľ: BIOWORLD TECHNOLOGY

Opis: Synthetic phosphopeptide derived from human PAK4 around the phosphorylation site of Serine 474.

Merná jednotka: 1 * 100 µG

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Katalógové číslo: (786-048)

Dodávateľ: G BIOSCIENCES

Opis: Chymostatin inhibits serine proteases having a chymotrypsin-like specificity, including α, β γ, and δ chymotrypsin, and most cysteine proteases including cathepsins B, H, L. Soluble in DMSO.

Merná jednotka: 1 * 5 mg

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Katalógové číslo: (BOSSBS-6281R-CY3)

Dodávateľ: BIOSS INC

Opis: This gene encodes a type II transmembrane serine protease. The encoded protein has an extracellular region that consists of two domains, a catalytic serine protease domain and a non-catalytic scavenger receptor cysteine-rich domain. This protein may be involved in diverse cellular functions including blood coagulation, maintenance of cell morphology and the growth and progression of certain cancers, particularly prostate cancer. Alternative splicing results in multiple transcript variants.

Merná jednotka: 1 * 100 µl

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Katalógové číslo: (BOSSBS-6281R-CY7)

Dodávateľ: BIOSS INC

Opis: This gene encodes a type II transmembrane serine protease. The encoded protein has an extracellular region that consists of two domains, a catalytic serine protease domain and a non-catalytic scavenger receptor cysteine-rich domain. This protein may be involved in diverse cellular functions including blood coagulation, maintenance of cell morphology and the growth and progression of certain cancers, particularly prostate cancer. Alternative splicing results in multiple transcript variants.

Merná jednotka: 1 * 100 µl

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Katalógové číslo: (BOSSBS-11993R)

Dodávateľ: BIOSS INC

Opis: Changes in the serine/threonine phosphorylation state of a protein in response to various external stimuli can have profound effects on cellular signal transduction, apoptosis and carcinogenesis. The reagents, including phosphorylated protein/peptides, antibodies against the phosphospecific amino acid, are important tools to explore the activation of serine, threonine or tyrosine containing proteins. An aberrant protein phosphorylation is a hallmark of human disease, and the enzymes, particularly protein kinases, which control protein phosphorylation are recognized as a major new drug target family.

Merná jednotka: 1 * 100 µl

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