Hľadali ste: Methyl+arachidonate

Dodávateľ: ENZO LIFE SCIENCES

Opis: A cell-permeable cGMP analog which is more resistant to phosphodiesterases than cGMP and which preferentially activates cGMP-dependent protein kinase. It inhibits thrombin stimulated arachidonic acid release in human platelets.

New Product

Katalógové číslo: (BOSSBS-6505R-A488)

Dodávateľ: BIOSS INC

Opis: Lipoxygenases are a family of enzymes which dioxygenate unsaturated fatty acids, thus initiating lipoperoxidation of membranes and synthesis of signaling molecules, as well as inducing structural and metabolic changes in the cell. The Lox enzymes in mammals include 12-LO and 15-LO, which are classified with respect to their positional specificity of the deoxygenation of their most common substrate, arachidonic acid. The metabolism of arachidonic acid leads to the generation of biologically active metabolites that have been implicated in cell growth and proliferation, as well as survival and apoptosis. 15-Lipoxygenase (15-LO) acts in physiological membrane remodeling and the pathogenesis of atherosclerosis, inflammation, and carcinogenesis. It is highly regulated and expressed in a tissue- and cell-type-specific fashion. IL-4 and IL-13 play important roles in transactivating the 15-LO gene. Overexpression of 15-LO type 1 in prostate cancer contributes to the cancer progression by regulating IGF-1R expression and activation.

Merná jednotka: 1 * 100 µl

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Dodávateľ: ENZO LIFE SCIENCES

Opis: Selective, potent cAMP-specific phosphodiesterase inhibitor (PDE IV, IC50=2µM). Inhibits superoxide generation and platelet aggregation stimulated by arachidonic acid. Also inhibits fMLP-induced neutrophil adhesion to vascular endothelial cells.

New Product

Katalógové číslo: (BOSSBS-13129R-HRP)

Dodávateľ: BIOSS INC

Opis: Acyl-CoA synthetases, also known as long-chain fatty-acid CoA synthases (FACL) or palmitoyl-CoA ligases, include ACSL1-6, which are all single-pass membrane proteins localizing to the mitochondrion, microsome or peroxisome. FACL proteins are important for synthesis of cellular lipids and for ∫-oxidation degradation. Specifically, ACSL proteins catalyze the activation of long-chain fatty acids to acyl-CoAs, which can be metabolized to form CO2, triacylglycerol (TAG), phospholipids (PL) and cholesteryl esters (CE). ACSL3 preferentially utilizes laurate, myristate, arachidonate and eicosapentaenoate among saturated and unsaturated long chain fatty acids. FACL3 is expressed as two isoforms in various tissues, including brain, heart, placenta, prostate, skeletal muscle, testis and thymus. FACL4 preferentially utilizes arachidonate and is abundant in steroidogenic tissues. FACL4 may modulate female fertility and uterine prostaglandin production.

Merná jednotka: 1 * 100 µl

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Katalógové číslo: (BOSSBS-12999R)

Dodávateľ: BIOSS INC

Opis: Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid composition.

Merná jednotka: 1 * 100 µl

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Dodávateľ: ENZO LIFE SCIENCES

Opis: AACOCF3 is a trifluoromethylketone derivative of arachidonic acid. It is a selective inhibitor of human cytosolic PLA2 and Ca2+-independent PLA2 (iPLA2, IC50=15 µM). It is active in intact platelets and U937 cells (IC50=8 µM). It also inhibits fatty acid amide hydrolase (100% at 7.5 µM).

New Product

Dodávateľ: ENZO LIFE SCIENCES

Opis: Beneficial effect in cardiovascular diseases and inflammation. Inhibits PGE2 formation from arachidonic acid in 3T3 fibroblats.

New Product

Katalógové číslo: (BOSSBS-0420R-CY7)

Dodávateľ: BIOSS INC

Opis: Mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling NK activity exerts an anti-abortive effect.

Merná jednotka: 1 * 100 µl

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Katalógové číslo: (BOSSBS-12999R-CY3)

Dodávateľ: BIOSS INC

Opis: Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid composition.

Merná jednotka: 1 * 100 µl

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Katalógové číslo: (BOSSBS-12999R-CY5)

Dodávateľ: BIOSS INC

Opis: Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid composition.

Merná jednotka: 1 * 100 µl

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Dodávateľ: ENZO LIFE SCIENCES

Opis: Inhibits PAF-induced platelet aggregation (IC50=8.4 µM) and collagen-induced aggregation (IC50=84.2 µM) with no effect on arachidonic acid or ADP induced aggregation. Inhibits PAF-induced bronchoconstriction in vivo in the guinea-pig (69% at 1.0 mg/kg).

New Product

Katalógové číslo: (BOSSBS-8572R-A750)

Dodávateľ: BIOSS INC

Opis: Selectively hydrolyses arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.

Merná jednotka: 1 * 100 µl

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Katalógové číslo: (BOSSBS-8572R-A680)

Dodávateľ: BIOSS INC

Opis: Selectively hydrolyses arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.

Merná jednotka: 1 * 100 µl

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Katalógové číslo: (BOSSBS-0420R)

Dodávateľ: BIOSS INC

Opis: Mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling NK activity exerts an anti-abortive effect.

Merná jednotka: 1 * 100 µl

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Katalógové číslo: (BOSSBS-0420R-FITC)

Dodávateľ: BIOSS INC

Opis: Mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling NK activity exerts an anti-abortive effect.

Merná jednotka: 1 * 100 µl

Predaj

Katalógové číslo: (BOSSBS-12999R-HRP)

Dodávateľ: BIOSS INC

Opis: Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid composition.

Merná jednotka: 1 * 100 µl

Predaj