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Image Unavailable-BOSSBS-7731R-FITC

Anti-TRIP1 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Katalógové číslo: (BOSSBS-7731R-FITC)
Dodávateľ: BIOSS INC
Opis: Human SUG1 (also known as p45, Rpt6, Cim3 and PSMC5) is a component of the 19S regulatory subunit of the 26S proteosome complex. It is one of the AAA ATPas found in the 19S regulatory complex that is thought to participate in the unfolding of ubiquitinated proteins in an ATP dependent manner. It has also been shown to directly interact with the nucleotide excision repair protein XPB.
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-1394R-FITC

Anti-Jab1 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Katalógové číslo: (BOSSBS-1394R-FITC)
Dodávateľ: BIOSS INC
Opis: The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors.
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-9453R-FITC

Anti-PYGB Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Katalógové číslo: (BOSSBS-9453R-FITC)
Dodávateľ: BIOSS INC
Opis: Glycolysis is an evolutionarily conserved series of ten chemical reactions that utilizes eleven enzymes to concomitantly generate pyruvate and ATP from glucose. fructose kinase-2/fructose 2,6-bisphosphatase (PFK-2) stimulates the synthesis and degradation of fructose 2,6-bisphosphate. Glycogen phosphorylase (also known as GP) is an allosteric enzyme important in carbohydrate metabolism. Its activity is regulated through either noncovalent binding of metabolites or by covalent modification. Glycogen phosphorylase catalyzes the phosphorylation of glycogen to Glc-1-P. There are three genes which encode the brain, liver and muscle forms of glycogen phosphorylase, PYGB, PYGL and PYGM. Because of its fundamental role in the metabolism of glycogen, glycogen phosphorylase has been a target for the design of inhibitory compounds, which could be valuable in the therapeutic treatment of type 2 diabetes mellitus.
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-9367R-FITC

Anti-PSMD6 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Katalógové číslo: (BOSSBS-9367R-FITC)
Dodávateľ: BIOSS INC
Opis: In eukaryotic cells, selective breakdown of cellular proteins is ensured by two distinct pathways, ubiquitination and degradation by the 26S proteasome. At specific stages of development, embryo- and tissue-specific components of the 26S proteasome are formed by developmentally regulated alternative splicing, including Rpn10a through Rpn10e (also designated pUb-R2 through pUb-R5). The pUb-R2 subunit, originally identified as S5a, is ubiquitously expressed and may perform proteolysis constitutively in a wide variety of cells. p44S10 is a highly conserved proteasome regulatory subunit that is expressed in heart, liver, skeletal muscle and pancreas. In addition to normal tissue expression, p44S10 is also expressed in several melanoma cell lines, such as MCF-7, 451Lu and WM164. Since forced expression of p44S10 in radial growth phase melanoma cells results in an increase in cellular proliferation, p44S10 may represent a potential link between regulation of proteasome activity and tumor cell proliferation in vivo.
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-2042R-FITC

Anti-CD33 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Katalógové číslo: (BOSSBS-2042R-FITC)
Dodávateľ: BIOSS INC
Opis: Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-9119R-FITC

Anti-COPS8 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Katalógové číslo: (BOSSBS-9119R-FITC)
Dodávateľ: BIOSS INC
Opis: The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-1012R-FITC

Anti-BMP2 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Katalógové číslo: (BOSSBS-1012R-FITC)
Dodávateľ: BIOSS INC
Opis: BMP2 belongs to the transforming growth factor-beta (TGFB) superfamily of secreted growth factors. It is a disulfide-linked homodimer and induces bone and cartilage formation. In addition to its osteogenic activity, BMP2 plays an important role in cardiac morphogenesis and is expressed in a variety of tissues including lung, spleen, brain, liver, prostate ovary and small intestine. The functional form of BMP2 is a 26 kDa protein composed of two identical 114 amino acid polypeptide chains linked by a single disulfide bond. BMPs control fundamental events in early embryonic development, organogenesis and adult tissue homeostasis.
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-13357R-FITC

Anti-ADRM1 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Katalógové číslo: (BOSSBS-13357R-FITC)
Dodávateľ: BIOSS INC
Opis: ADRM1 is a 407 amino acid protein that localizes to both the nucleus and the cytoplasm and is thought to be involved in protein recruitment and cell adhesion. An integral membrane protein, ADRM1 functions to recruit UCH-L5, a deubiquitinating enzyme, to the 26S proteasome, and once at the proteasome it promotes the activity of UCH-L5. Additionally, ADRM1 is thought to mediate lymphocyte adhesion in endothelial cells and may thus play a role in lymphocyte homing. ADRM1 expression is induced by IFN-g in some cancer cell lines and its expression is upregulated in other metastatic cells, suggesting a role in carcinogenesis. Two isoforms of ADRM1 exist due to alternative splicing events.
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-9366R-FITC

Anti-PSMD7 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Katalógové číslo: (BOSSBS-9366R-FITC)
Dodávateľ: BIOSS INC
Opis: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 17.
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-2706R-FITC

Anti-SIGLEC10 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Katalógové číslo: (BOSSBS-2706R-FITC)
Dodávateľ: BIOSS INC
Opis: SIGLEC10 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. It preferentially binds to alpha2,3- or 2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. SIGLEC10 interacts with PTPN6/SHP-1 upon phosphorylation. The protein is expressed by peripheral blood leukocytes (eosinophils, monocytes and a natural killer cell subpopulation).
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-1372R-FITC

Anti-PSMD9 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Katalógové číslo: (BOSSBS-1372R-FITC)
Dodávateľ: BIOSS INC
Opis: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMD9 is a non-ATPase subunit of the 19S regulator.
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-13527R-FITC

Anti-GPR26 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Katalógové číslo: (BOSSBS-13527R-FITC)
Dodávateľ: BIOSS INC
Opis: G protein-coupled receptors (GPRs) are a protein family of transmembrane receptors that transmit an extracellular signal (ligand binding) into an intracellular signal (G protein activation). GPR signaling is an ancient evolutionarily mechanism used by all eukaryotes to sense environmental stimuli and mediate cell-cell communication. GPRs have seven membrane-spanning domains and the extracellular domains are often glycosylated. These extracellular loops also contain two highly conserved cysteine residues which create disulfide bonds to stabilize the receptor structure. GPR26 (G-protein coupled receptor 26) is a 337 amino acid protein that is primarily expressed in regions of the brain. GPR26 is characterized as an ‘orphan’ G protein-coupled receptor, which is a receptor that binds an unidentified natural ligand. Due to evidence of GPR26 being downregulated in glioblastomas, it has been suggested that GPR26 may be a suppressor of early glioma development.
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-9609R-FITC

Anti-RBM26 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Katalógové číslo: (BOSSBS-9609R-FITC)
Dodávateľ: BIOSS INC
Opis: Proteins containing RNA recognition motifs, including various hnRNP proteins, are implicated in the regulation of alternative splicing and protein components of snRNPs. The RBM (RNA-binding motif) gene family encodes proteins with an RNA binding motif that have been suggested to play a role in the modulation of apoptosis. RBM26 (RNA binding motif protein 26), whose alternative names include CTCL tumor antigen se70-2, C13orf10, ARRS2, SE70-2, ZC3H17, PRO1777, FLJ20957, RP11-255E21.1, MGC133295 or MGC133296, is a 1,007 amino acid protein with six isoforms which result due to alternative splicing. RBM26 also contains one C3H1-type zinc finger and two RRM (RNA recognition motif) domains. The gene encoding RBM26 maps to human chromosome 13q31.1.
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-12406R-FITC

Anti-SNX4 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Katalógové číslo: (BOSSBS-12406R-FITC)
Dodávateľ: BIOSS INC
Opis: SNX2 and SNX4 share a high degree of amino acid similarity with SNX1, as they all contain a characteristic phox homology (PX) domain (4). These proteins are all partially associated with cellular membranes, and they, likewise, associate with EGF, PDGF and insulin receptor tyrosine kinases (2). These nexins are widely expressed and yet have various tissue distribution patterns. Additionally, the sorting nexins can associate with each other and with a variety of other cellular proteins, suggesting that they exist as part of multisubunit complexes (1,5). The related protein, SNX3, comprises a distinct subgroup of nexins that share less sequence similarity outside of the PX domain and have dramatically different binding affinities for the tyrosine kinase receptors (2,6).
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-9104R-FITC

Anti-TNKS Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Katalógové číslo: (BOSSBS-9104R-FITC)
Dodávateľ: BIOSS INC
Opis: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1. Stimulates 26S proteasome activity.
Merná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-3300R-FITC

Anti-NFKB1 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Katalógové číslo: (BOSSBS-3300R-FITC)
Dodávateľ: BIOSS INC
Opis: This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].
Merná jednotka: 1 * 100 µl
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