Hľadali ste: WYE-125132

Dodávateľ: ENZO LIFE SCIENCES

Opis: Highly potent, ATP-competitive, and specific mTOR kinase inhibitor. Antiproliferative.

Dodávateľ: CAYMAN

Opis: WYE-125132 is an ATP-competitive inhibitor of mTOR (IC₅₀ = 0,19 nM) that inhibits signaling through both mTORC1 and mTORC2. It is selective for mTOR over phosphatidylinositol 3-kinase isoforms. WYE-125132 is effective against mTORC1 and mTORC2 in diverse cancer models, both <i>in vitro</i> and <i>in vivo</i>. Oral administration of WYE-125132 alone blocks mTOR signaling and prevents tumor growth in breast, lung, renal, and glioma cancer xenografts in mice, while combination therapy with the VEGF-inhibitor bevacizumab causes complete regression of A498 renal carcinoma tumors. In addition to its applications in cancer, WYE-125132 has been used to delineate novel aspects of mTOR signaling.