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Image Unavailable-BOSSBS-6124R-CY7

Anti-NBN Rabbit Polyclonal Antibody (Cy7®)

Katalógové číslo: (BOSSBS-6124R-CY7)
Dodávateľ: BIOSS INC
Opis: Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability. Forms a complex with RBBP8 to link DNA double-strand break sensing to resection. Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex.
Merná jednotka: 1 * 100 µl
Product Image-TB07

Western blots, pre-made, human single tissue single species

Dodávateľ: G BIOSCIENCES
Opis: Ready-to-screen, human, single tissue blots, from both normal and tumour tissues. G-Biosciences pre-made blots are prepared with the appropriate GenLysate™ and 50 μg protein is loaded onto a 4 to 20% denaturing polyacrylamide gel, along with a prestained molecular weight marker. After the proteins are resolved, they are transferred to a PVDF membrane, using our Western transfer buffer.

Product Image-ENZOENZ42813

Bio-16-ddUTP, tetralithium salt

Katalógové číslo: (ENZOENZ42813)
Dodávateľ: ENZO LIFE SCIENCES
Opis: Bio-16-ddUTP (Biotin-16-2’,3’-dideoxyuridine-5’-triphosphate) can be used for 3’-end labelling of single-stranded or double-stranded DNA. It is especially useful as a substrate for terminal transferase for the 3’-terminal addition of a single Bio-16-ddUMP. Biotin-labelled oligonucleotides produced by this reaction are suitable as hybridisation probes and nucleic acid array assays. It is also a substrate for Taq DNA polymerase and other DNA polymerases.
Merná jednotka: 1 * 25 Nmo
Product Image-391-0639

VWR® Adhesive Sealing Strips, PP, 1×8

Katalógové číslo: (391-0639)
Dodávateľ: VWR Collection
Opis: 1x8 adhesive sealing strips are ideal for use with 1x8 strip-well ELISA plates.
Merná jednotka: 1 * 400 items
Product Image-BURK5393-8011

PharmaDispo Disposable Powder Samplers

Dodávateľ: BURKLE
Opis: PharmaDispo disposable powder sampler is a multi-target sampler that takes three separate target point samples with a single sampling.

New Product

Product Image-620-2643

VWR® TD20, TD21, TD22, Teploměr přesný, univerzální, vodotěsný

Dodávateľ: VWR Collection
Opis: Vodotěsné teploměry, které lze opakovaně kalibrovat poskytují vysoce přesné výsledky při měření teploty kapalin, vzduchu nebo teploty uvnitř předmětů (s vpichovým senzorem); rukojeť a kabel senzoru jsou odolné až do 250 °C (trvalá provozní teplota 230 °C); vhodné pro laboratoře, aplikace kontroly kvality, servis, potravinářský průmysl atd.

Product Image-620-9100

VWR® Traceable®, Dishwasher Thermometer

Katalógové číslo: (620-9100)
Dodávateľ: VWR Collection
Opis: This thermometer ensures proper cleaning by providing proof that the required temperature of 82 °C is met during dishwashing. Designed for applications in wet laboratories, wash-down areas and outdoors. Used in food, pharmaceutical, cleanrooms, and industrial laboratories. Waterproof metal with internal stainless steel sensor.
Merná jednotka: 1 * 1 items
Product Image-BURK5387-0100

Sampling siphons

Dodávateľ: BURKLE
Opis: Disposable plunging samplers acting like siphons.

Product Image-521-4029

Rotors, Avanti JLA-16.250

Dodávateľ: Beckman Coulter
Opis: J-LITE JLA-16.250 fixed angle (high performance) aluminium rotor, with single lock lid, 6×250 ml, 16000 rpm, 38400 ×g. For use in Avanti J Series and J2 Series centrifuges. Maximum speed is 14000 rpm in J2 Series centrifuges

Product Image-620-0226

Fold-back thermometer PT1000, TLC 1598

Katalógové číslo: (620-0226)
Dodávateľ: EBRO
Opis: This thermometer with foldable high accuracy PT1000 penetration sensor can be used for fast, accurate temperature monitoring in incoming goods inspections, catering, food products industry, trade and cool storage.
Merná jednotka: 1 * 1 items
Image Unavailable-SGEA09262015

SGE OptChem™ Single Taper Inlet Liners

Dodávateľ: Trajan Scientific and Medical
Opis: SGE OptChem™ GC inlet liner provide optimal performance with advanced coating technologies in an easy to use format for GC and GCMS.

Product Image-BOHLP1720-16

Temperature probes, Lemo®, BOLA

Dodávateľ: Bohlender
Opis: Used for temperature measurement in aggressive liquids and cable provides flexible connection from measuring device to medium.

Product Image-115-3055

Single wire disposable wrist strap, SCS

Katalógové číslo: (115-3055)
Dodávateľ: DESCO
Opis: Wrist strap (2209) is designed for one-time use. The wrist strap is ideally suited for shipment along with ESD sensitive items [ESDS], providing the means to ground personnel opening ESDS packaging and installing contents.
Merná jednotka: 1 * 1 items
Product Image-KIMB7172

Dispensers for toilet paper, Professional® Aquarius®

Katalógové číslo: (KIMB7172)
Dodávateľ: KIMBERLY CLARK
Opis: This Professional® Aquarius® black single sheet toilet tissue dispenser designed to be used with a range of Kleenex® and Scott® single sheet format toilet tissue.
Merná jednotka: 1 * 1 items
Product Image-460-3237

VWR®, Bloky a příslušenství pro blokové termostaty

Dodávateľ: VWR Collection
Opis: Solid blocks: For use as a low temperature hotplate or for custom drilling.

Image Unavailable-BOSSBS-6124R-CY5

Anti-NBN Rabbit Polyclonal Antibody (Cy5®)

Katalógové číslo: (BOSSBS-6124R-CY5)
Dodávateľ: BIOSS INC
Opis: Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability. Forms a complex with RBBP8 to link DNA double-strand break sensing to resection. Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex.
Merná jednotka: 1 * 100 µl
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